Structures of proteins of biomedical interest from the Center for Eukaryotic Structural Genomics
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  • 作者:George N. Phillips Jr. (1)
    Brian G. Fox (1)
    John L. Markley (1)
    Brian F. Volkman (2)
    Euiyoung Bae (1)
    Eduard Bitto (1)
    Craig A. Bingman (1)
    Ronnie O. Frederick (1)
    Jason G. McCoy (1)
    Betsy L. Lytle (2)
    Brad S. Pierce (3)
    Jikui Song (1)
    Simon N. Twigger (4)
  • 关键词:Structural genomics ; CESG ; Medical relevance ; High ; throughput structure determination
  • 刊名:Journal of Structural and Functional Genomics
  • 出版年:2007
  • 出版时间:September 2007
  • 年:2007
  • 卷:8
  • 期:2-3
  • 页码:73-84
  • 全文大小:519KB
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  • 作者单位:George N. Phillips Jr. (1)
    Brian G. Fox (1)
    John L. Markley (1)
    Brian F. Volkman (2)
    Euiyoung Bae (1)
    Eduard Bitto (1)
    Craig A. Bingman (1)
    Ronnie O. Frederick (1)
    Jason G. McCoy (1)
    Betsy L. Lytle (2)
    Brad S. Pierce (3)
    Jikui Song (1)
    Simon N. Twigger (4)

    1. Center for Eukaryotic Structural Genomics, Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA
    2. Medical College of Wisconsin, Milwaukee, WI, 53226, USA
    3. Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA
    4. Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA
文摘
The Center for Eukaryotic Structural Genomics (CESG) produces and solves the structures of proteins from eukaryotes. We have developed and operate a pipeline to both solve structures and to test new methodologies. Both NMR and X-ray crystallography methods are used for structure solution. CESG chooses targets based on sequence dissimilarity to known structures, medical relevance, and nominations from members of the scientific community. Many times proteins qualify in more than one of these categories. Here we review some of the structures that have connections to human health and disease.

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