Mikrofluidisches 3D-Zellkulturmodell der Blut-Hirn-Schranke

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• 作者：Heiko Kiessling (1)
  Ingo Schulz (2)
  Eleonore Haltner (3)
  Gert Fricker (4)
  Martin Stelzle (1)
  Julia Sch眉tte (1)
  
  1. Naturwissenschaftliches und Medizinisches Institut (NMI) ; Universit盲t T眉bingen ; Markwiesenstra脽e 55 ; D-72770 ; Reutlingen ; Deutschland
  2. Microfluidic Chipshop GmbH ; Jena ; Deutschland
  3. Across Barriers GmbH ; Saarbr眉cken ; Deutschland
  4. Institut f眉r Pharmazie und Molekulare Biotechnologie (IPMB) ; Universit盲t Heidelberg ; Heidelberg ; Deutschland
  
• 刊名：BIOspektrum
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：21
• 期：2
• 页码：175-178
• 全文大小：505 KB
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  10. Sch眉tte, J, Hagmeyer, B, Holzner, F (2011) 鈥淎rtificial micro organs鈥?鈥?a microfluidic device for dielectrophoretic assembly of liver sinusoids. Biomed Microdevices 13: pp. 493-501 CrossRef
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• 刊物主题：Life Sciences, general; Biochemistry, general; Human Genetics; Microbiology; Developmental Biology; Pharmacology/Toxicology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1868-6249

文摘

State of the art animal and cell culture models fail to predict the ability of drugs to cross the blood-brain barrier as they lack comparability to the complex human situation. The development of novel pharmaceutics therefore requires in vitro models with human like cell response. Therefore, we are developing a model which mimics the organ environment including the specific 3D arrangement of different cell types, extracellular matrix, and perfusion by combining biology, biochemistry and microfluidic technology.