Results of children with renal tumors treated in the Austrian–Hungarian Wilms Tumor Study 1989 and the International Society of Pediatric Oncology (SIOP) 93-01/GPOH trial in Austria
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- 作者：Claudia Zimmermann (1)
Ulrike P?tschger (2)
Gabriele Amann (3)
Ernst Horcher (4)
Karin Dieckmann (5)
Karoly Lakatos (1)
Christian Urban (6)
Herwig Lackner (6)
Michael H?llwarth (7)
Bernhard Meister (8)
Roman Crazzolara (8)
Georg Ebetsberger (9)
Franz Martin Fink (10)
Neil Jones (11)
Agnes Gamper (11)
Reinhard Moser (12)
Reinhold Kerbl (12)
Barbara Jauk (13)
Walter Pobegen (13)
Martin Henkel (14)
Bernd Ausserer (15)
Waltraud Friesenbichler (1)
Judith B?hm (1)
Norbert Graf (16)
Wolfgang Holter (1) (2)
Helmut Gadner (1) (2)
Andreas Zoubek (1)
Leo Kager MD (1) (2) - 关键词：Wilms tumor ; Nephroblastoma ; Neoadjuvant treatment trials ; Austrian children
- 刊名：memo - Magazine of European Medical Oncology
- 出版年：2012
- 出版时间：December 2012
- 年：2012
- 卷：5
- 期：4
- 页码：289-295
- 全文大小：786KB
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12. Warmann SW, Furtw?ngler R, Blumenstock G, et al. Tumor biology influences the prognosis of nephroblastoma patients with primary pulmonary metastases: results from SIOP 93-01/GPOH and SIOP 2001/GPOH. Ann Surg. 2011;254(1):155-2. CrossRef
13. Fuchs J, Szavay P, Luithle T, et al. Surgical implications for liver metastases in nephroblastoma—data from the SIOP/GPOH study. Surg Oncol. 2008;17(1):33-0. CrossRef
14. Fuchs J, Kienecker K, Furtw?ngler K, et al. Surgical aspects in the treatment of patients with unilateral wilms tumor: a report from the SIOP 93-01/German Society of Pediatrics Oncology and Hematology. Ann Surg. 2009;249:666-1. CrossRef
15. Paya K, Horcher E, Rauhofer U, et al. Bilateral Wilms-tumor—surgical aspects. Eur J Pediatr Surg. 2001;11(2):99-04. CrossRef
16. Cozzi F, Schiavetti A, Morini F, et al. Re: partial nephrectomy for unilateral wilms tumor: results of study SIOP 93-01/GPOH. J Urol. 2004;171:2383. CrossRef
17. Delemarre JF, Sandstedt B, Harms B, et al. The new SIOP (Stockholm) working classification of renal tumours of childhood. International Society of Paediatric Oncology. Med Pediatr Oncol. 1996;26(2):145-. CrossRef
18. Bernstein L, Linet M, Smith MA, et al. Renal tumors. Cancer incidence and survival among children and adolescents: 1975-995. United States SEER Program. 1999;79-0.
19. Meadows AT, Friedman DL, Neglia JP, et al. Second neoplasms in survivors of childhood cancer: findings from the Childhood Cancer Survivor Study cohort. J Clin Oncol. 2009;27(14):2356-2. CrossRef - 作者单位：Claudia Zimmermann (1)
Ulrike P?tschger (2)
Gabriele Amann (3)
Ernst Horcher (4)
Karin Dieckmann (5)
Karoly Lakatos (1)
Christian Urban (6)
Herwig Lackner (6)
Michael H?llwarth (7)
Bernhard Meister (8)
Roman Crazzolara (8)
Georg Ebetsberger (9)
Franz Martin Fink (10)
Neil Jones (11)
Agnes Gamper (11)
Reinhard Moser (12)
Reinhold Kerbl (12)
Barbara Jauk (13)
Walter Pobegen (13)
Martin Henkel (14)
Bernd Ausserer (15)
Waltraud Friesenbichler (1)
Judith B?hm (1)
Norbert Graf (16)
Wolfgang Holter (1) (2)
Helmut Gadner (1) (2)
Andreas Zoubek (1)
Leo Kager MD (1) (2)
1. St. Anna Kinderspital, Department of Pediatrics, Medical University, Kinderspitalgasse 6, 1090, Vienna, Austria
2. St. Anna Kinderkrebsforschung, CCRI, Vienna, Austria
3. Institute of Clinical Pathology, Medical University, Vienna, Austria
4. Department of Pediatric Surgery, Medical University, Vienna, Austria
5. Department of Radiotherapy, Medical University, Vienna, Austria
6. Department of Pediatrics and Adolescent Medicine, Medical University, Graz, Austria
7. Department of Pediatric and Adolescent Surgery, Medical University, Graz, Austria
8. Department of Pediatrics, Medical University, Innsbruck, Austria
9. Department of Pediatrics, LFKK, Linz, Austria
10. Department of Pediatrics, Bezirkskrankenhaus, St. Johann/Tirol, Austria
11. Department of Pediatrics, Landeskrankenhaus und Universit?tsklinikum, Salzburg, Austria
12. Department of Pediatrics, Landeskrankenhaus, Leoben-Eisenerz, Austria
13. Department of Pediatrics, Landeskrankenhaus, Klagenfurt, Austria
14. Department of Pediatrics, Hospital of the Sisters of Mercy, Linz, Austria
15. Department of Pediatrics, Landeskrankenhaus, Dornbirn, Austria
16. Department of Pediatrics, Medical University, Homburg/Saar, Germany
文摘
The overall outcome for children with nephroblastomas is excellent when treated according to protocols that include surgery, chemotherapy, and, in selected cases, radiotherapy. This study was conducted to provide population-based data on Austrian children who had been treated in neoadjuvant nephroblastoma trials between October 1988 and July 2001. One hundred and forty-eight children with newly diagnosed untreated renal tumors were registered in the Austrian–Hungarian Wilms Tumor Study (AHWTS) 1989 (N--3) and the SIOP 93-01/GPOH Study (N--5). After a median follow-up of 11.8 years from diagnosis, 130 patients have been reported to be alive; 18 patients have died. Three patients had carcinoma and three had nephroblastomatosis; the 5-year event-free survival (EFS) and overall survival (OS) rates for the remaining 142 patients were 83?±-?% and 91?±-?%, respectively (SIOP 93-01/GPOH trial, 5-year EFS 85?±-?%, OS 95?±-?%; AHWTS 1989 trial, 5-year EFS 79?±-?%, OS 86?±-?%). Outcome was better for low-risk pathology (N--4; 5-year EFS 92?±-?%, OS 100?%) than for intermediate-risk (N--06; 5-year EFS 89?±-?%, OS 94?±-?%) and high-risk pathology (N--2; 5-year EFS 50?±-1?%, OS 68?±-0?%; P-lt;-.001). The stage of the disease was correlated with outcome; stages I–III (N--02; 5-year EFS 90?±-?%, OS 95?±-?%), stage IV (N--5; 5-year EFS 56?±-0?%, OS 76?±-?%), and stage V (N--5; 5-year EFS 80?±-0?%, OS 87?±-?%; P--.008). On the basis of the expected incidence for renal tumors in childhood, these data provide evidence that almost all children with these diseases in Austria had been recruited in the respective treatment trials (mean: 12 patients/year); and the outcomes are comparable to international results.