The aetiological association between the dynamics of cortisol productivity and ADHD

详细信息    查看全文

• 作者：Rebecca Pinto ; Fruhling Rijsdijk ; Isabelle Ouellet-Morin…
• 刊名：Journal of Neural Transmission
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：123
• 期：8
• 页码：991-1000
• 全文大小：504 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Neurology
  Pharmacology and Toxicology
  Psychiatry
  
• 出版者：Springer Wien
• ISSN：1435-1463
• 卷排序：123

文摘

Attention-deficit/hyperactivity disorder (ADHD) has been linked to dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis, indexed by salivary cortisol. The phenotypic and aetiological association of cortisol productivity with ADHD was investigated. A selected twin design using 68 male twin-pairs aged 12–15, concordant or discordant for high ADHD symptom scores, or control twin-pairs with low ADHD symptoms, based on developmentally stable parental ADHD ratings. A genetic growth curve model was applied to cortisol samples obtained across three points during a cognitive-electroencephalography assessment, to examine the aetiological overlap of ADHD affection status (high versus low ADHD symptom scores) with latent intercept and slope factors. A significant phenotypic correlation emerged between ADHD and the slope factor, with cortisol levels dropping faster for the group with high ADHD symptom scores. The analyses further suggested this overlap was mostly driven by correlated genetic effects. We identified change in cortisol activity over time as significantly associated with ADHD affection status, primarily explained by shared genetic effects, suggesting that blunted cortisol productivity can be a marker of genetic risk in ADHD.KeywordsAttention deficit/hyperactivity disorder (ADHD)CortisolHypothalamic–pituitary–adrenal (HPA) axisGrowth curve modelling (GCM)Twin studyDevelopmental psychiatry