Novel pH-sensitive nanoformulated docetaxel as a potential therapeutic strategy for the treatment of cholangiocarcinoma
详细信息 查看全文
- 作者：Nan Du (1)
Lin-Ping Song (1)
Xiao-Song Li (1)
Lei Wang (2)
Ling Wan (1)
Hong-Ying Ma (1)
Hui Zhao (1)
1. The Second Department of Oncology ; The First Affiliated Hospital of the General Hospital of the PLA ; Beijing ; 100048 ; China
2. Department of Medical ; The First Affiliated Hospital of the General Hospital of the PLA ; No. 51 Fucheng Road ; Haidian District ; Beijing ; 100048 ; China - 关键词：Cholangiocarcinoma ; Polymeric micelles ; Docetaxel ; Apoptosis ; Cancer chemotherapy
- 刊名：Journal of Nanobiotechnology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：13
- 期：1
- 全文大小：2,170 KB
- 参考文献：1. Khan, SA, Davidson, BR, Goldin, RD, Heaton, N, Karani, J, Pereira, SP (2012) Guidelines for the diagnosis and treatment of cholangiocarcinoma: an update. Gut 61: pp. 1657-69 CrossRef
2. Patel, T (2011) Cholangiocarcinoma-controversies and challenges. Nat Rev Gastroenterol Hepatol 8: pp. 189-200 CrossRef
3. Vauthey, JN, Blumgart, LH (1994) Recent advances in the management of cholangiocarcinomas. Semin Liver Dis 14: pp. 109-14 CrossRef
4. Patel, T (2001) Increasing incidence and mortality of primary intrahepatic cholangiocarcinoma in the United States. Hepatology 33: pp. 1353-7 CrossRef
5. Matull, WR, Khan, SA, Pereira, SP (2006) Impact of classification of hilar cholangiocarcinomas (Klatskin tumors) on incidence of intra- and extrahepatic cholangiocarcinoma in the United States. J Natl Cancer Inst 21: pp. 873-5
6. Parkin, DM, Srivatanakul, P, Khlat, M, Chenvidhya, D, Chotiwan, P, Insiripong, S (1991) Liver cancer in Thailand. I. A case鈥揷ontrol study of cholangiocarcinoma. Int J Cancer 48: pp. 323-8 CrossRef
7. Seehofer, D, Kamphues, C, Neuhaus, P (2008) Management of bile duct tumors. Expert Opin Pharmacother 9: pp. 2843-56 CrossRef
8. Khan, SA, Thomas, HC, Davidson, BR, Robinson, SDT (2005) Cholangiocarcinoma. Lancet 366: pp. 1303-10 CrossRef
9. Tong, R, Cheng, J (2007) Anticancer polymeric nanomedicines. Polym Rev 3: pp. 345-81 CrossRef
10. Mura, S, Nicolas, J, Couvreur, P (2013) Stimuli-responsive nanocarriers for drug delivery. Nat Mater 12: pp. 991-1003 CrossRef
11. Murakami, M, Cabral, H, Matsumoto, Y, Wu, S, Kano, MR, Yamori, T (2011) Improving drug potency and efficacy by nanocarrier-mediated subcellular targeting. Sci Transl Med 3: pp. 64ra2 CrossRef
12. Owens, DE, Peppas, NA (2006) Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. Int J Pharm 307: pp. 93-102 CrossRef
13. Wu, XL, Kim, JH, Koo, H, Bae, SM, Shin, H, Kim, MS (2010) Tumor-targeting peptide conjugated pH-responsive micelles as a potential drug carrier for cancer therapy. Bioconjug Chem 21: pp. 208-13 CrossRef
14. Lv, Y, Ding, G, Zhai, J, Guo, Y, Nie, G, Xu, L (2013) A superparamagnetic Fe3O4-loaded polymeric nanocarrier for targeted delivery of evodiamine with enhanced antitumor efficacy. Colloids Surf B Biointerfaces 110: pp. 411-8 CrossRef
15. Li, F, Na, K (2011) Self-assembled chlorin e6 conjugated chondroitin sulfate nanodrug for photodynamic therapy. Biomacromolecules 12: pp. 1724-30 CrossRef
16. Lundberg, P, Lynd, NA, Zhang, Y, Zeng, X, Krogstad, DV, Paffen, T (2013) pH-triggered self-assembly of biocompatible histamine-functionalized triblock copolymers. Soft Matter 9: pp. 82-9 CrossRef
17. Huang ZJ, Yang N, Xu TW, Lin JQ. Antitumor efficacy of docetaxel-loaded nanocarrier against esophageal cancer cell bearing mice model. Drug Res (Stuttg). 2014. [Epub ahead of print].
18. Noori Koopaei, M, Khoshayand, MR, Mostafavi, SH, Amini, M, Khorramizadeh, MR, Jeddi Tehrani, M (2014) Docetaxel loaded PEG-PLGA nanoparticles: optimized drug loading, in-vitro cytotoxicity and in-vivo antitumor effect. Iran J Pharm Res 13: pp. 819-33
19. Matsumura, Y (2011) Preclinical and clinical studies of NK012, an SN-38-incorporating polymeric micelles, which is designed based on EPR effect. Adv Drug Deliv Rev 63: pp. 184-92 CrossRef
20. Yu, S, Wu, G, Gu, X, Wang, J, Wang, Y, Gao, H (2013) Magnetic and pH-sensitive nanoparticles for antitumor drug delivery. Colloids Surf B Biointerfaces 103: pp. 1522
21. Ramasamy, T, Kim, JH, Choi, JY, Tran, TH, Choi, HG, Yong, CS (2014) pH sensitive polyelectrolyte complex micelles for highly effective combination chemotherapy. J Mater Chem B 2: pp. 6324 CrossRef
22. Danhier, F, Feron, O, Preat, V (2010) To exploit the tumor microenvironment: passive and active tumor targeting of nanocarriers for anti-cancer drug delivery. J Controlled Release 148: pp. 135-46 CrossRef
23. Knight, V, Koshkina, NV, Waldrep, JC, Giovanella, BC, Gilbert, BE (1999) Anticancer exffect of 9-nitrocamptothecin liposome aerosol on human cancer xenografts in nude mice. Cancer Chemother Pharmacol 44: pp. 177-86 CrossRef - 刊物类别：Chemistry and Materials Science
- 刊物主题：Biotechnology
Nanotechnology - 出版者：BioMed Central
- ISSN：1477-3155
文摘
Background Cholangiocarcinoma (CC) is one of the fatal malignant neoplasms with poor prognosis. The traditional chemotherapy has been resistant to CC and does not improve the quality of life. The aim of the present study is to investigate the potential of chondroitin sulphate (CS)-histamine (HS) block copolymer micelles to improve the chemotherapeutic efficacy of docetaxel (DTX). Results pH-responsive property of CS-HS micelles was utilized to achieve maximum therapeutic efficacy in CC. In the present study, docetaxel-loaded CS-HS micelles (CSH-DTX) controlled the release of drug in the basic pH while rapidly released its cargo in the tumor pH (pH 5 and 6.8) possibly due to the breakdown of polymeric micelles. A nanosize of th to that of control and half to that of free drug treated group with no sign of drug-related adverse effects. Immunohistochemical analysis of tumor sections showed that fewer number of Ki-67 cells were present in CSH-DTX treated group comparing to that of free DTX treated group. Conclusion Our data suggests that nanoformulation of DTX could potentially improve the chemotherapy treatment in cholangiocarcinoma as well as in other malignancies.