Brief Report: Antibodies Reacting to Brain Tissue in Basque Spanish Children with Autism Spectrum Disorder and Their Mothers

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• 作者：Christy C. Rossi (1) (2) (7)
  Joaquin Fuentes (3)
  Judy Van de Water (2) (4) (5)
  David G. Amaral (1) (2) (6)
  
• 关键词：Autism spectrum disorders ; Autoantibody ; Brain ; International
• 刊名：Journal of Autism and Developmental Disorders
• 出版年：2014
• 出版时间：February 2014
• 年：2014
• 卷：44
• 期：2
• 页码：459-465
• 全文大小：415 KB
• 作者单位：Christy C. Rossi (1) (2) (7)
  Joaquin Fuentes (3)
  Judy Van de Water (2) (4) (5)
  David G. Amaral (1) (2) (6)
  
  1. Department of Psychiatry and Behavioral Sciences, University of California, Davis, Sacramento, CA, USA
  2. The MIND Institute, University of California, Davis, 2825 50th Street, Sacramento, CA, 95817, USA
  7. Department of Psychology, University of Denver, Denver, CO, USA
  3. Child and Adolescent Psychiatry Unit, Policlinica Guipuzkoa and Gautena Autism Society, Donostia/San Sebastián, Spain
  4. Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, Sacramento, CA, USA
  5. NIEHS Center for Children’s Environmental Health, University of California, Davis, Sacramento, CA, USA
  6. Center for Neuroscience and California National Primate Research Center, University of California, Davis, Sacramento, CA, USA
  
• ISSN：1573-3432

文摘

Previous investigations found that a subset of children with autism spectrum disorder (ASD) in California possessed plasma autoantibodies that reacted intensely with brain interneurons or other neural profiles. Moreover, for several cohorts of American women, maternal autoantibody reactivity to specific fetal brain proteins was highly specific to mothers of children with ASD. We sought to determine whether children and their mothers from a regionally specific cohort from the Basque Country of Spain demonstrated similar reactivity. Some children’s plasma reacted to interneurons, beaded axons or other neural profiles with no difference in the occurrence of these antibodies in children with or without ASD. Findings on the maternal antibodies confirmed previous research; plasma reactivity to fetal brain a combination of proteins at 37 and 73?kDa or 39 and 73?kDa was found exclusively in mothers of children with ASD.