Complete resolution of steroid-resistant organizing pneumonia associated with myelodysplastic syndrome following allogeneic hematopoietic cell transplantation

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• 作者：Takeru Asano ; Nobuharu Fujii ; Daigo Niiya ; Hisakazu Nishimori ; Keiko Fujii&#8230
• 关键词：Organizing pneumonia ; Myelodysplastic syndrome ; Sweet鈥檚 syndrome ; Allogeneic hematopoietic cell transplantation
• 刊名：SpringerPlus
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：3
• 期：1
• 全文大小：956KB
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• 作者单位：Takeru Asano (10)
  Nobuharu Fujii (10) (11)
  Daigo Niiya (10)
  Hisakazu Nishimori (10) (11)
  Keiko Fujii (10) (11)
  Ken-ichi Matsuoka (10)
  Koichi Ichimura (12)
  Toshihisa Hamada (13)
  Eisei Kondo (10)
  Yoshinobu Maeda (10)
  Yasushi Tanimoto (10)
  Katsuji Shinagawa (10)
  Mitsune Tanimoto (10)
  
  10. Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Hospital, Okayama, Japan
  11. Division of Transfusion, Okayama University Hospital, Okayama, Japan
  12. Department of Pathology, Okayama University Hospital, Okayama, Japan
  13. Department of Dermatology, Okayama University Hospital, Okayama, Japan
  
• 刊物类别：Science, general;
• 刊物主题：Science, general;
• 出版者：Springer International Publishing
• ISSN：2193-1801

文摘

Pulmonary complications in patients with hematological malignancies are often caused by infection but are sometimes associated with an underlying disease such as organizing pneumonia (OP). Here, we report a case of life-threatening steroid-resistant OP associated with myelodysplastic syndrome (MDS) and successfully performed allogeneic hematopoietic cell transplantation (HSCT). A 33-year-old female with refractory anemia with excess blasts-1 that had progressed from refractory anemia with ringed sideroblasts and concomitant Sweet鈥檚 syndrome was admitted. Multiple pulmonary infiltrates were revealed on a chest computed tomography scan, which progressively worsened even after chemotherapy and corticosteroid therapy. No evidence of infection was observed in bronchoalveolar lavage fluid. A histological examination of a transbronchial lung biopsy specimen showed lymphocyte invasion with fibrosis, indicating that the pulmonary infiltrates were OP associated with MDS. Before transplantation, she suffered from respiratory failure and required oxygen supplementation. She developed idiopathic pneumonitis syndrome on day 61 that responded well to corticosteroid therapy, and the OP pulmonary infiltrates improved gradually after HSCT, She was discharged on day 104 and is well without recurrence of OP or MDS 2 years after HSCT. Keywords Organizing pneumonia Myelodysplastic syndrome Sweet鈥檚 syndrome Allogeneic hematopoietic cell transplantation