A specific mode of microsatellite instability is a crucial biomarker in adult T-cell leukaemia/lymphoma patients
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- 作者：Kaname Miyashita ; Kei Fujii ; Kenichi Taguchi…
- 关键词：Microsatellite instability ; DNA mismatch repair ; Adult T ; cell leukaemia/lymphoma ; Chemotherapy ; Drug resistance ; Biomarker
- 刊名：Journal of Cancer Research and Clinical Oncology
- 出版年：2017
- 出版时间：March 2017
- 年：2017
- 卷：143
- 期：3
- 页码：399-408
- 全文大小：923KB
- 刊物类别：Medicine
- 刊物主题：Oncology; Cancer Research; Internal Medicine; Hematology;
- 出版者：Springer Berlin Heidelberg
- ISSN：1432-1335
- 卷排序：143
文摘
PurposeMicrosatellite instability (MSI) has been a long-standing biomarker candidate for drug resistance in tumour cells. Despite numerous clinical studies, the data in the literature are not conclusive. The complexity of the MSI phenomenon in some malignancies may, at least partly, account for the discrepancy. In addition, methodological problems are also pointed out in the assay techniques. We previously established a unique fluorescent technique in which the major methodological problems in conventional assays are overcome. Application of this technique has revealed two distinct modes of microsatellite alterations, i.e. Type A and Type B. More importantly, we demonstrated that Type A MSI is the direct consequence of defective DNA mismatch repair (MMR) that causes cellular resistance against antineoplastic agents.