Fusion Image of Positron Emission Tomography and Computed Tomography for the Diagnosis of Local Recurrence of Rectal Cancer

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• 作者：Hiroki Fukunaga MD (1)
  Mitsugu Sekimoto MD ; PhD (1)
  Masataka Ikeda MD ; PhD (1)
  Ichiro Higuchi MD (1)
  Masayoshi Yasui MD (1)
  Iwao Seshimo MD (1)
  Osamu Takayama MD (1)
  Hirofumi Yamamoto MD ; PhD (1)
  Masayuki Ohue MD ; PhD (1)
  Mitsuaki Tatsumi MD ; PhD (2)
  Jun Hatazawa MD ; PhD (2)
  Masakazu Ikenaga MD ; PhD (3)
  Tsunehiko Nishimura MD ; PhD (4)
  Morito Monden MD ; PhD (1)
  
• 关键词：PET ; CT ; Fusion image ; Local recurrence of rectal cancer
• 刊名：Annals of Surgical Oncology
• 出版年：2005
• 出版时间：July 2005
• 年：2005
• 卷：12
• 期：7
• 页码：561-569
• 全文大小：257KB
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• 作者单位：Hiroki Fukunaga MD (1)
  Mitsugu Sekimoto MD, PhD (1)
  Masataka Ikeda MD, PhD (1)
  Ichiro Higuchi MD (1)
  Masayoshi Yasui MD (1)
  Iwao Seshimo MD (1)
  Osamu Takayama MD (1)
  Hirofumi Yamamoto MD, PhD (1)
  Masayuki Ohue MD, PhD (1)
  Mitsuaki Tatsumi MD, PhD (2)
  Jun Hatazawa MD, PhD (2)
  Masakazu Ikenaga MD, PhD (3)
  Tsunehiko Nishimura MD, PhD (4)
  Morito Monden MD, PhD (1)
  
  1. Department of Surgery and Clinical Oncology (E2), Graduate School of Medicine, Osaka University, 2-2 Yamadaoka Suita,Kinetics (D9), Osaka, 565-0871, Japan
  2. Department of Nuclear Medicine and Tracer Kinetics (D9), Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan
  3. Department of Surgery, Osaka National Hospital, 2-1-14 Hoenzaka, Chuo-ku, Osaka, 540-0006, Osaka, Japan
  4. Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii, Kawaramachi-Hirokoji, Kamigyo, Kyoto, 602-8566, Japan
  

文摘

Background The aim of this study was to evaluate the clinical and therapeutic value of digital fusion image (FI) of positron emission tomography (PET) using 18F-fluorodeoxy glucose and computed tomography (CT) in patients who were suspected of having a local recurrence of rectal cancer. Methods Forty-two patients (32 men and 10 women; mean age, 61.4 years, range, 40-9 years) with a suspicion of local recurrence after curative resection of rectal cancer were prospectively recruited and underwent 18F-fluorodeoxy glucose-PET and CT. The FI was reconstructed with a commercially available digital software program, T-B Fusion. Wilcoxon signed rank test was used to compare FI with CT alone or PET alone. Results FI yielded a correct diagnosis in 39 (93%) of 42 patients, whereas CT alone and PET alone did so in 33 (79%) and 37 (88%) patients, respectively. FI had better diagnostic accuracy than CT alone (P = .0138) and PET alone (P = .0156). Overall, FI altered patient management in 11 (26.2%) patients on the basis of additional information, including differentiation of the tumor from the postoperative scar in 6 patients, exact anatomical location in 3 patients, and both in 2 patients. Conclusions FI has a potential clinical value in the treatment of suspected local recurrence of rectal cancer.