Correlation of GLUT-1 Overexpression, Tumor Size, and Depth of Invasion with 18F-2-fluoro-2-deoxy-d -glucose Uptake by Positron Emission Tomography in Colorectal Cancer

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• 作者：Jinyu Gu ; Hirofumi Yamamoto ; Hiroki Fukunaga ; Katsuki Danno ; Ichiro Takemasa ; Masataka Ikeda ; Mitsuaki Tatsumi ; Mitsugu Sekimoto ; Jun Hatazawa and Tsunehiko Nishimura ; et al.
• 关键词：Standardized uptake value ; 18F ; 2 ; fluoro ; 2 ; deoxy ; d ; glucose ; Positron emission tomography ; Colorectal cancer ; Glucose transporter ; 1
• 刊名：Digestive Diseases and Sciences
• 出版年：2006
• 出版时间：December, 2006
• 年：2006
• 卷：51
• 期：12
• 页码：2198-2205
• 全文大小：462 KB

文摘

We investigated the wide variability of 18F-2-fluoro-2-deoxy-d-glucose (FDG) uptake, semiquantified as standardized uptake value (SUV), in positron emission tomography (PET) scanning, in 20 patients with colorectal cancer (CRC), including 1 with synchronous hepatic metastasis. The sensitivity of PET in CRC diagnosis was 100 % , with a mean SUV of 8.0 (3.1R11;11.9). Tumor size and depth of invasion were associated with higher SUVs (P=.0004, .042, respectively). Strong glucose transporter-1 (GLUT-1) expression had significantly positive correlation with the SUV (r=.619, P=.003). GLUT-1 expression revealed positive staining in 17 (85 % ) of the 20 primary lesions. The central part of the tumor, thought to be relatively hypoxic, had stronger GLUT-1 expression and a higher SUV than the periphery, in both the primary tumor and hepatic metastatic foci. Our data suggest that the SUVs of FDG uptake in PET may be a noninvasive biomarker for advanced CRC, indicative of a large hypoxic tumor with deep invasion.