Anti-inflammatory effect of fullerene C60 in a mice model of atopic dermatitis

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• 作者：Nadezda Shershakova ; Elena Baraboshkina ; Sergey Andreev…
• 关键词：Fullerene C60 ; Atopic dermatitis ; Mouse model ; Cytokine
• 刊名：Journal of Nanobiotechnology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：14
• 期：1
• 全文大小：1,311 KB
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• 作者单位：Nadezda Shershakova (1)
  Elena Baraboshkina (1)
  Sergey Andreev (1)
  Daria Purgina (1)
  Irina Struchkova (1)
  Oleg Kamyshnikov (1)
  Alexandra Nikonova (1)
  Musa Khaitov (1)
  
  1. NRC Institute of Immunology FMBA of Russia, Moscow, Russia
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Biotechnology
  Nanotechnology
  
• 出版者：BioMed Central
• ISSN：1477-3155

文摘

Background Water-soluble form of fullerene C₆₀ is a promising tool for the control of ROS-dependent inflammation including allergic diseases. Anti-inflammatory effects of C₆₀ (nC₆₀) aqueous dispersion were evaluated in the mouse models of atopic dermatitis using subcutaneous (SC) and epicutaneous (EC) applications during 50 days period. A highly stable nC₆₀ was prepared by exhaustive dialysis of water-organic C₆₀ solution against water, where the size and ζ-potential of fullerene nanoparticles are about 100 nm and −30 mV, respectively.