Target Plate Material Influence on Fullerene-C60 Laser Desorption/Ionization Efficiency

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• 作者：Guido P. Zeegers ; Barbara F. Günthardt…
• 关键词：C60 ; Electrical conductivity ; Electrical resistivity ; Electrospray deposition ; Fullerene ; Ionization mechanism ; LDI ; MALDI ; Thermal conductivity
• 刊名：Journal of The American Society for Mass Spectrometry
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：27
• 期：4
• 页码：699-708
• 全文大小：1,480 KB
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• 作者单位：Guido P. Zeegers (1)
  Barbara F. Günthardt (1)
  Renato Zenobi (1)
  
  1. Department of Chemistry and Applied Biosciences, ETH Zürich, Vladimir-Prelog-Weg 3, CH-8093, Zürich, Switzerland
  
• 刊物主题：Analytical Chemistry; Biotechnology; Organic Chemistry; Proteomics; Bioinformatics;
• 出版者：Springer US
• ISSN：1879-1123

文摘

Systematic laser desorption/ionization (LDI) experiments of fullerene-C₆₀ on a wide range of target plate materials were conducted to gain insight into the initial ion formation in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. The positive and negative ion signal intensities of precursor, fragment, and cluster ions were monitored, varying both the laser fluence (0–3.53 Jcm−2) and the ion extraction delay time (0–950 ns). The resulting species-specific ion signal intensities are an indication for the ionization mechanisms that contribute to LDI and the time frames in which they operate, providing insight in the (MA)LDI primary ionization. An increasing electrical resistivity of the target plate material increases the fullerene-C₆₀ precursor and fragment anion signal intensity. Inconel 625 and Ti90/Al6/V4, both highly electrically resistive, provide the highest anion signal intensities, exceeding the cation signal intensity by a factor ~1.4 for the latter. We present a mechanism based on transient electrical field strength reduction to explain this trend. Fullerene-C₆₀ cluster anion formation is negligible, which could be due to the high extraction potential. Cluster cations, however, are readily formed, although for high laser fluences, the preferred channel is formation of precursor and fragment cations. Ion signal intensity depends greatly on the choice of substrate material, and careful substrate selection could, therefore, allow for more sensitive (MA)LDI measurements.