Comparative Analysis of the Antineoplastic Activity of C₆₀ Fullerene with 5-Fluorouracil and Pyrrole Derivative In Vivo

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• 作者：O. V. Lynchak ; Yu I. Prylutskyy ; V. K. Rybalchenko…
• 关键词：C60 fullerene ; 5 ; Fluorouracil ; Pyrrole derivative ; Colorectal cancer ; Small ; angle X ; ray scattering ; Molecular modeling
• 刊名：Nanoscale Research Letters
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：12
• 期：1
• 全文大小：583KB
• 刊物主题：Nanotechnology; Nanotechnology and Microengineering; Nanoscale Science and Technology; Nanochemistry; Molecular Medicine;
• 出版者：Springer US
• ISSN：1556-276X
• 卷排序：12

文摘

The antitumor activity of pristine C₆₀ fullerene aqueous solution (C₆₀FAS) compared to 5-fluorouracil (5-FU) and pyrrole derivative 1-(4-Cl-benzyl)-3-Cl-4-(CF₃-fenylamino)-1H-pyrrol-2.5-dione (MI-1) cytostatic drugs was investigated and analyzed in detail using the model of colorectal cancer induced by 1.2-dimethylhydrazine (DMH) in rats. The number, size, and location of the tumors were measured, and the pathology was examined. It was found that the number of tumors and total lesion area decreased significantly under the action of C₆₀FAS and MI-1. Because these drugs have different mechanisms of action, their simultaneous administration can potentially increase the effectiveness and significantly reduce the side effects of antitumor therapy.