Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study
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- 作者：Daniele Campa (1) (2)
Barbara Pardini (3)
Alessio Naccarati (3)
Ludmila Vodickova (3)
Jan Novotny (4)
Verena Steinke (5)
Nils Rahner (5)
Elke Holinski-Feder (6)
Monika Morak (6)
Hans K Schackert (7)
Heike G?rgens (7)
Judith K?tting (8)
Beate Betz (9)
Matthias Kloor (10)
Christoph Engel (11)
Reinhard Büttner (12)
Peter Propping (5)
Asta F?rsti (1) (13)
Kari Hemminki (1) (13)
Roberto Barale (2)
Pavel Vodicka (3)
Federico Canzian (1) - 刊名：BMC Gastroenterology
- 出版年：2010
- 出版时间：December 2010
- 年：2010
- 卷：10
- 期：1
- 全文大小：232KB
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39. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-230X/10/112/prepub - 作者单位：Daniele Campa (1) (2)
Barbara Pardini (3)
Alessio Naccarati (3)
Ludmila Vodickova (3)
Jan Novotny (4)
Verena Steinke (5)
Nils Rahner (5)
Elke Holinski-Feder (6)
Monika Morak (6)
Hans K Schackert (7)
Heike G?rgens (7)
Judith K?tting (8)
Beate Betz (9)
Matthias Kloor (10)
Christoph Engel (11)
Reinhard Büttner (12)
Peter Propping (5)
Asta F?rsti (1) (13)
Kari Hemminki (1) (13)
Roberto Barale (2)
Pavel Vodicka (3)
Federico Canzian (1)
1. Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany
2. Department of Biology, University of Pisa, Pisa, Italy
3. Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic
4. Department of Oncology, First Faculty of Medicine, Charles University, Prague, Czech Republic
5. Institute of Human Genetics, University of Bonn, Bonn, Germany
6. Department of Internal Medicine, Campus Innenstadt, University Hospital of Ludwig-Maximilians-University, Munich, Germany
7. Department of Surgical Research, Technische Universit?t Dresden, Dresden, Germany
8. Medical Department, Knappschaftskrankenhaus, Ruhr University, Bochum, Germany
9. Institute of Human Genetics, University of Düsseldorf, Düsseldorf, Germany
10. Department of Applied Tumour Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany
11. Institute of Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
12. Institute of Pathology, University of Bonn, Bonn, Germany
13. Center for Primary Health Care Research, Clinical Research Center, Lund University, Malm?, Sweden
文摘
Background Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor (GHSR), has two major functions: the stimulation of the growth hormone production and the stimulation of food intake. Accumulating evidence also indicates a role of ghrelin in cancer development. Methods We conducted a case-control study to examine the association of common genetic variants in the genes coding for ghrelin (GHRL) and its receptor (GHSR) with colorectal cancer risk. Pairwise tagging was used to select the 11 polymorphisms included in the study. The selected polymorphisms were genotyped in 680 cases and 593 controls from the Czech Republic. Results We found two SNPs associated with lower risk of colorectal cancer, namely SNPs rs27647 and rs35683. We replicated the two hits, in additional 569 cases and 726 controls from Germany. Conclusion A joint analysis of the two populations indicated that the T allele of rs27647 SNP exerted a protective borderline effect (Ptrend = 0.004).