GLI2 inhibition abrogates human leukemia stem cell dormancy
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- 作者：Anil Sadarangani ; Gabriel Pineda ; Kathleen M Lennon…
- 关键词：Leukemia stem cells ; Cell cycle ; PF ; 04449913 ; Sonic hedgehog ; Smoothened SMO ; GLI2
- 刊名：Journal of Translational Medicine
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：13
- 期：1
- 全文大小：3,745 KB
- 刊物主题：Biomedicine general; Medicine/Public Health, general;
- 出版者：BioMed Central
- ISSN：1479-5876
文摘
Background Dormant leukemia stem cells (LSC) promote therapeutic resistance and leukemic progression as a result of unbridled activation of stem cell gene expression programs. Thus, we hypothesized that 1) deregulation of the hedgehog (Hh) stem cell self-renewal and cell cycle regulatory pathway would promote dormant human LSC generation and 2) that PF-04449913, a clinical antagonist of the GLI2 transcriptional activator, smoothened (SMO), would enhance dormant human LSC eradication.