Peripheral blood complete remission after splenic irradiation in Mantle-Cell Lymphoma with 11q22-23 deletion and ATM inactivation

详细信息    查看全文

• 作者：Andrea Riccardo Filippi (1)
  Pierfrancesco Franco (1)
  Marco Galliano (2)
  Umberto Ricardi (1)
  
• 刊名：Radiation Oncology
• 出版年：2006
• 出版时间：December 2006
• 年：2006
• 卷：1
• 期：1
• 全文大小：148KB
• 参考文献：1. Campo E, Raffeld M, Jaffe ES: Mantle-Cell Lymphoma. / Semin Hemat 1999, 36: 115鈥?27.
  2. Witzig TE: Current treatment approaches for Mantle-Cell Lymphoma. / J Clin Oncol 2005, 23: 6409鈥?414. CrossRef
  3. Andersen NS, Jensen MK, de Nully Brown P, Geisler CH: A Danish population-based analysis of 105 mantle cell lymphoma patients: incidences, clinical features, response, survival and prognostic factors. / Eur J Cancer 2002, 38: 401鈥?08. CrossRef
  4. Peghini PE, Fehr J: Analysis of Cyclin D1 expression by Quantitative Real-Time Reverse Transcription-Polymerase Chain Reaction in the diagnosis of Mantle Cell Lymphoma. / Am J Clin Pathol 2002, 117: 237鈥?45. CrossRef
  5. Weinmann M, Becker G, Einsele H, Bamberg M: Clinical indications and biological mechanisms of splenic irradiation in chronic leukaemias and myeloproliferative disorders. / Radiother Oncol 2001, 58: 235鈥?46. CrossRef
  6. Wagner H Jr, McKeough PG, Desforges J, Madoc-Jones H: Splenic irradiation in the treatment of patients with chronic myelogenous leukemia or myelofibrosis with myeloid metaplasia. Results of daily and intermittent fractionation with and without concomitant hydroxyurea. / Cancer 1986, 58: 1204鈥?207. CrossRef
  7. De Rossi G, Biagnini C, Lopez M, Tombolini V, Mandelli F: Treatment by splenic irradiation in 22 chronic lymphocytic leukemia patients. / Tumori 1982, 68: 511鈥?14.
  8. Elliott MA, Tefferi A: Splenic irradiation in myelofibrosis with myeloid metaplasia: a review. / Blood Rev 1999, 13: 163鈥?70. CrossRef
  9. McFarland JT, Kuzma C, Millard FE, Johnstone PA: Palliative irradiation of the spleen. / Am J Clin Oncol 2003, 26: 178鈥?83. CrossRef
  10. Muncunill J, Villa S, Domingo A, Domenech P, Arnaiz MD, Callis M: Splenic irradiation as primary therapy for prolymphocytic leukemia. / Br J Hematol 1990, 76: 305鈥?06. CrossRef
  11. Sharp RA, MacWalter RS: A role for splenic irradiation in the treatment of hairy-cell leukaemia. Case report and review of the literature. / Acta Haematol 1983, 70: 59鈥?2. CrossRef
  12. Thomson AE, Vaughan-Smith S, Peel WE, Wetherley-Mein G: The intrinsic radiosensitivity of lymphocytes in chronic lymphocytic leukaemia, quantitatively determined independently of cell death rate factors. / Int J Radiat Biol Relat Stud Phys Chem Med 1985, 48: 943鈥?61. CrossRef
  13. Sgarabotto D, Vianello F, Radossi P, Poletti A, Sotti G, Stefani PM, Sartori R, Girolami A: Remission in hairy-cell leukaemia-variant following splenic radiotherapy alone. / Leuk Lymphoma 1997, 26: 395鈥?98.
  14. Chisesi T, Capnist G, Dal Fior S: Splenic irradiation in chronic lymphocytic leukaemia. / Eur J Hematol 1991, 46: 202鈥?04. CrossRef
  15. Kiss A, Haubenstock A, Bognar H, Scheiderbauer R, al-Mobarak M, Base W: Splenic irradiation as primary therapy for prolymphocytic leukaemia. / Am J Hematol 1989, 30: 188鈥?89. CrossRef
  16. Delic J, Magdelenat H, Barbaroux C, Chaillet MP, Dubray B, Gluckman E, Fourquet A, Girinsky T, Cosset JM: In-vivo induction of apoptosis in human lymphocytes by therapeutic fractionated total body irradiation. / Br J Radiol 1995, 68: 997鈥?003. CrossRef
  17. Paule B, Cosset JM, Le Bourgeois JP: The possible role of splenic irradiation in chronic lymphocytic leukaemia: a critical review. / Radiother Oncol 1985, 4: 45鈥?4. CrossRef
  18. De Ruysscher D, Waer M, Vandeputte M, Aerts R, Vantongelen K, van der Schueren E: Changes of lymphocyte subsets after local irradiation for early stage breast cancer and seminoma testis : Long term increase of activated (HLA-DR +) T cells and decrease of 'naive' (CD4/CD45R) T lymphocytes. / Eur J Cancer 1992, 28A: 1729鈥?734. CrossRef
  19. Bessler H, Notti I, Cohen AM, Klein B, Djaldetti M: Inhibition of leukemic cell proliferation by factor (s) released from irradiated lymphocytes of B-chronic lymphocytic leukaemia patients. / Am J Hematol 1994, 46: 65鈥?1. CrossRef
  20. Little JB: Cellular radiation effects and the bystander response. / Mut Res 2006, 597: 113鈥?18.
  21. Kaminski JM, Shinohara E, Summers JB, Niermann KJ, Morimoto A, Brousal J: The controversial abscopal effect. / Cancer Treat Rev 2005, 31: 159鈥?72. CrossRef
  22. Prise KM, Schettino G, Folkard M, Held KD: New insights on cell death from radiation exposure. / Lancet Oncol 2005, 6: 520鈥?28. CrossRef
  23. Schaffner C, Idler I, Stilgenbauer S, Dohner H, Lichter P: Mantle cell lymphoma is characterized by inactivation of the ATM gene. / Proc Nat Acad Sci USA 2000, 97: 2773鈥?778. CrossRef
  24. Camacho E, Hernandez L, Hernandez S, Tort F, Bellosillo B, Bea S, Bosch F, Montserrat E, Cardesa A, Fernandez PL, Campo E: ATM gene inactivation in mantle cell lymphoma mainly occurs by truncating mutations and missense mutations involving the phosphatidylinositol-3 kinase domain and is associated with increasing numbers of chromosomal imbalances. / Blood 2002, 99: 238鈥?4. CrossRef
  25. Fang NY, Greiner TC, Weisenburger DD, Chan WC, Vose JM, Smith LM, Armitage JO, Mayer RA, Pike BL, Collins FS, Hacia JG: Oligonucleotide microarrays demonstrate the highest frequency of ATM mutations in the mantle cell subtype of lymphoma. / Proc Nat Acad Sci USA 2003, 100: 5372鈥?377. CrossRef
  26. M'kacher R, Bennaceur A, Farace F, Lauge A, Plassa LF, Wittmer E, Dossou J, Violot D, Deutsch E, Bourhis J, Stoppa-Lyonnet D, Ribrag V, Carde P, Parmentier C, Berheim A, Turhan AG: Multiple molecular mechanisms contribute to radiation sensitivity in mantle cell lymphoma. / Oncogene 2003, 22: 7905鈥?912. CrossRef
  27. Stilgenbauer S, Winkler D, Ott G, Schaffner C, Leupolt E, Bentz M, Moller P, Muller-Hermelink HK, James MR, Lichter P, Dohner H: Molecular characterization of 11q deletions points to a pathogenetic role of ATM gene in mantle cell lymphoma. / Blood 1999, 94: 3262鈥?264.
  
• 作者单位：Andrea Riccardo Filippi (1)
  Pierfrancesco Franco (1)
  Marco Galliano (2)
  Umberto Ricardi (1)
  
  1. Radiation Oncology, University of Torino, Ospedale S. Giovanni Battista, Torino, Italy
  2. Medical Oncology, Ospedale Alba-Bra-ASL 18, Alba-Bra, Italy
  

文摘

Mantle Cell Lymphoma (MCL) is a well-known histological and clinical subtype of B-cell non-Hodgkin's Lymphomas. It is usually characterized by an aggressive disease course, presenting with advanced stage disease at diagnosis and with low response rates to therapy. However few cases of indolent course MCL have been described. We herein report a case of MCL with splenomegaly and peripheral blood involvement as main clinical features. The patient underwent moderate dose splenic radiation therapy and achieved spleen downsizing and peripheral blood complete remission. Splenic irradiation has been extensively used in the past as palliative treatment in several lymphoproliferative disorders and a systemic effect and sometimes peripheral blood complete remissions have been observed. Mainly advocated mechanisms responsible for this phenomenon are considered direct radiation-induced apoptotic cell death, immune modulation via proportional changes of lymphocyte subsets due to known differences in intrinsic radiosensitivity and a radiation-induced cytokine release. The peculiar intrinsic radiosensitivity pattern of lymphoid cells could probably be explained by well-defined individual genetic and molecular features. In this context, among NHLs, MCL subtype has the highest rate of ATM (Ataxia Teleangiectasia Mutated) inactivation. While the ATM gene is thought to play a key-role in detecting radiation-induced DNA damage (expecially Double Strand Breaks), recent in vitro data support the hypothesis that ATM loss may actually contribute to the radiosensitivity of MCL cells. ATM status was retrospectively investigated in our patient, with the tool of Fluorescence In Situ Hybridization, showing a complete inactivation of a single ATM allele secondary to the deletion of chromosomal region 11q22-23. The presence of this kind of cytogenetic aberration may be regarded in the future as a potential predictive marker of radiation response.