Biological Basis of Depression in Adults with Diabetes
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- 作者：Shivam Champaneri (1)
Gary S. Wand (2)
Saurabh S. Malhotra (3)
Sarah S. Casagrande (1)
Sherita Hill Golden (4) - 关键词：Diabetes ; Depression ; Type 2 diabetes ; Obesity ; Metabolic syndrome ; Hypothalamic ; pituitary ; adrenal (HPA) axis ; Sympathetic nervous system ; Cortisol ; Catecholamines ; Inflammation ; Inflammatory markers ; Cytokines ; Insulin resistance ; Cortisol awakening response ; Diurnal cortisol ; Awakening cortisol ; Visceral fat ; Heart rate variability ; Adipocytokines ; C ; reactive protein (CRP) ; Interleukin ; 6 (IL ; 6)
- 刊名：Current Diabetes Reports
- 出版年：2010
- 出版时间：December 2010
- 年：2010
- 卷：10
- 期：6
- 页码：396-405
- 全文大小：227KB
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Gary S. Wand (2)
Saurabh S. Malhotra (3)
Sarah S. Casagrande (1)
Sherita Hill Golden (4)
1. Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
2. Department of Medicine and Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
3. Department of Medicine, Indiana University, Indianapolis, IN, USA
4. Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, 2024 East Monument Street, Suite 2-616, Baltimore, MD, 21205, USA
文摘
Diabetes and depression are common comorbid conditions. Although certain health behaviors and risk factors partially explain the association of depression and diabetes, other potential mechanisms have yet to be elucidated. Certain neuroendocrine alterations such as activation of the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system (SNS) may contribute to the association. Additionally, presence of a proinflammatory state shown in recent literature in both diabetes and depression may contribute to this as well. The objectives of this review are to summarize and review the recent evidence showing alterations of these three biological systems—HPA axis, SNS, and inflammatory cascade—in depression, diabetes, and diabetes-related risk factors.