An emerging role for gasotransmitters in the control of breathing and ionic regulation in fish

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• 作者：Steve Perry ; Y. Kumai ; C. S. Porteus ; V. Tzaneva…
• 关键词：Nitric oxide ; Hydrogen sulphide ; Carbon monoxide ; Ionocyte ; Neuroepithelial cell ; Ventilation ; Chemoreception ; Osmoregulation ; Heme oxygenase ; Zebrafish
• 刊名：Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：186
• 期：2
• 页码：145-159
• 全文大小：1,115 KB
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• 作者单位：Steve Perry (1)
  Y. Kumai (1)
  C. S. Porteus (1) (2)
  V. Tzaneva (1)
  R. W. M. Kwong (1)
  
  1. Department of Biology, University of Ottawa, 30 Marie Curie, Ottawa, ON, K1N6N5, Canada
  2. Biosciences, College of Life and Environmental Sciences, University of Exeter, Exeter, EX4 4QD, UK
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Biochemistry
  Biomedicine
  Human Physiology
  Zoology
  Animal Physiology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-136X

文摘

Three gases comprising nitric oxide, carbon monoxide and hydrogen sulphide, collectively are termed gasotransmitters. The gasotransmitters control several physiological functions in fish by acting as intracellular signaling molecules. Hydrogen sulphide, first implicated in vasomotor control in fish, plays a critical role in oxygen chemoreception owing to its production and downstream effects within the oxygen chemosensory cells, the neuroepithelial cells. Indeed, there is emerging evidence that hydrogen sulphide may contribute to oxygen sensing in both fish and mammals by promoting membrane depolarization of the chemosensory cells. Unlike hydrogen sulphide which stimulates breathing in zebrafish, carbon monoxide inhibits ventilation in goldfish and zebrafish whereas nitric oxide stimulates breathing in zebrafish larvae while inhibiting breathing in adults. Gasotransmitters also modulate ionic uptake in zebrafish. Though nothing is known about the role of CO, reduced activities of branchial Na+/K+-ATPase and H+-ATPase activities in the presence of NO donors suggest an inhibitory role of NO in fish osmoregulation. Hydrogen sulphide inhibits Na+ uptake in zebrafish larvae and contributes to lowering Na+ uptake capacity in fish acclimated to Na+-enriched water whereas it stimulates Ca2+ uptake in larvae exposed to Ca2+-poor water. Keywords Nitric oxide Hydrogen sulphide Carbon monoxide Ionocyte Neuroepithelial cell Ventilation Chemoreception Osmoregulation Heme oxygenase Zebrafish