Homozygosity mapping and sequencing identify two genes that might contribute to pointing behavior in hunting dogs

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• 作者：Denis A Akkad ; Wanda M Gerding ; Robin B Gasser…
• 关键词：Dog ; Gene chip ; NGS ; Pointing ; Behavior
• 刊名：Canine Genetics and Epidemiology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：2
• 期：1
• 全文大小：2099KB
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• 作者单位：Denis A Akkad (1)
  Wanda M Gerding (1)
  Robin B Gasser (2)
  J枚rg T Epplen (1) (3)
  
  1. Human Genetics, Ruhr University Bochum, Universitaetsstrasse 150, Bochum, 44801, Germany
  2. Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, 3010, Australia
  3. Faculty of Health, University Witten-Herdecke, Alfred-Herrhausen-Strasse 50, Witten, 58448, Germany
  
• 刊物类别：Gene Function; Veterinary Medicine;
• 刊物主题：Gene Function; Veterinary Medicine;
• 出版者：BioMed Central
• ISSN：2052-6687

文摘

Background The domestic dog represents an important model for studying the genetics of behavior. In spite of technological advances in genomics and phenomics, the genetic basis of most specific canine behaviors is largely unknown. Some breeds of hunting dogs exhibit a behavioral trait called 鈥減ointing鈥?(a prolonged halt of movement to indicate the position of a game animal). Here, the genomes of pointing dogs (Large Munsterlander and Weimaraner) were compared with those of behaviorally distinct herding dogs (Berger des Pyren茅es and Schapendoes). We assumed (i) that these four dog breeds initially represented inbred populations and (ii) that selective breeding for pointing behavior promotes an enrichment of the genetic trait in a homozygous state.