Radical Gastrectomy Combined with Modified Gastric Bypass Surgery for Gastric Cancer Patients with Type 2 Diabetes

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• 作者：Tao Liu ; Guang-wei Xie ; Qing-zhong Tian ; Jin Li
• 关键词：Radical gastrectomy ; Gastric cancer ; Type 2 diabetes mellitus ; Roux ; en ; y anastomosis
• 刊名：Cell Biochemistry and Biophysics
• 出版年：2015
• 出版时间：July 2015
• 年：2015
• 卷：72
• 期：3
• 页码：839-844
• 全文大小：450 KB
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• 作者单位：Tao Liu (1)
  Guang-wei Xie (1)
  Qing-zhong Tian (1)
  Jin Li (1)
  
  1. Department of Surgical Oncology, Xuzhou Hospital Affiliated to Southeast University (Xuzhou Central Hospital), Xuzhou, 221009, Jiangsu, China
  
• 刊物主题：Biochemistry, general; Pharmacology/Toxicology; Biotechnology; Cell Biology; Biophysics and Biological Physics;
• 出版者：Springer US
• ISSN：1559-0283

文摘

The aim of the study is to explore the effectiveness of radical gastrectomy with modified gastric bypass surgery in treating gastric cancer patients with type 2 diabetes mellitus (T2DM). A total of 93 patients with gastric cancer and T2DM were treated in our hospital and enrolled in this study. Patients in group A (n?=?30) had a body mass index (BMI) of >28?kg/m2. Radical total gastrectomy and modified esophagojejunal Roux-en-y anastomosis were performed on 13 patients, and radical distal subtotal gastrectomy and gastric remnant jejunal Roux-en-y anastomosis were performed on 17 patients. The data from groups B, C, and D were derived from 63 patients with gastric cancer and diabetes who were admitted to our hospital from January 2005 to July 2012. All patients underwent radical gastrectomy (including 21 cases of gastric cancer surgery with Billroth I anastomosis, 25 cases of radical gastrectomy with Roux-en-Y anastomosis and BMI >28?kg/m2, and 17 cases with BMI <28?kg/m2). The BMI, fasting blood glucose (FBG), meal after the 2-hour glucose (2?h PBG), C-peptide (C-P), and glycosylated hemoglobin (HbAIC) data were collected before and 6 and 12?months after surgery. In groups A and D, BMI, FBG, 2?h PBG, C-P, and HbAIC at the 6th and 12th post-operative months were significantly lower than those before the surgery. In group B, BMI, FBG, 2?h PBG, C-P, and HbAIC at the 6th and 12th post-operative months did not decrease significantly, when compared with the pre-operative levels. In group C, BMI, FBG, 2?h PBG, C-P, and HbAIC at the 6th and 12th post-operative months decreased but showed no statistical significance. However, in comparison, groups A C showed significant differences after the surgeries. Radical gastrectomy combined with modified gastric bypass surgery is effective in treating patients with gastric cancer with type 2 diabetes, although this requires further investigation.