Gastropod-derived haemocyte extracellular traps entrap metastrongyloid larval stages of Angiostrongylus vasorum, Aelurostrongylus abstrusus and Troglostrongylus brevior
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- 作者：Malin K. Lange ; Felipe Penagos-Tabares ; Tamara Muñoz-Caro…
- 关键词：Gastropod ; borne diseases ; Metastrongyloidea ; Extracellular traps ; Lungworm ; Innate immune response
- 刊名：Parasites & Vectors
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：10
- 期：1
- 全文大小：3226KB
- 刊物主题：Parasitology; Entomology; Tropical Medicine; Infectious Diseases; Veterinary Medicine/Veterinary Science; Virology;
- 出版者：BioMed Central
- ISSN：1756-3305
- 卷排序：10
文摘
BackgroundPhagocyte-derived extracellular traps (ETs) were recently demonstrated mainly in vertebrate hosts as an important effector mechanism against invading parasites. In the present study we aimed to characterize gastropod-derived invertebrate extracellular phagocyte trap (InEPT) formation in response to larval stages of important canine and feline metastrongyloid lungworms. Gastropod haemocytes were isolated from the slug species Arion lusitanicus and Limax maximus, and the snail Achatina fulica, and exposed to larval stages of Angiostrongylus vasorum, Aelurostrongylus abstrusus and Troglostrongylus brevior and investigated for gastropod-derived InEPT formation.