Expression of AP-2γ in placentas of patients with preeclampsia and of smokers

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• 作者：Hannah A. Schneider ; Ulrich Gembruch ; Rolf Fimmers…
• 关键词：Activator protein 2 ; γ ; AP ; 2γ ; Preeclampsia ; Smoker ; Placenta
• 刊名：Archives of Gynecology and Obstetrics
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：291
• 期：5
• 页码：1015-1021
• 全文大小：580 KB
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• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Gynecology
  Obstetrics and Perinatology
  Endocrinology
  Human Genetics
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0711

文摘

Introduction There is evidence of a probable key role of the activator protein-2 γ (AP-2γ) in placental development. It is still an open question whether AP-2γ expression may be influenced by preeclampsia, which is a serious pregnancy complication, or by smoking, which has deleterious effects on trophoblastic development. Material and Methods Thus, the expression of AP-2γ was studied in trophoblastic epithelium and endothelium of placentas from patients with preeclampsia (n?=?43) and smokers (n?=?45) as well as placentas of healthy pregnant women (control group, n?=?26) between gestational ages 23 and 43?weeks. To allow differential expression in primary, secondary and tertiary villi, AP-2γ expression (arbitrary units) was determined immunohistologically. Results In preeclamptic placentas trophoblastic as well as endothelial cells AP-2γ expression was significantly higher compared to that in control placentas. Endothelial AP-2γ expression in placentas from smokers was similar to that of healthy women while trophoblastic AP-2γ expression in smokers-placenta was insignificantly higher compared to that of control placentas. In all three groups expression rates of AP-2γ did not differ between primary, secondary and tertiary villi. Conclusion A correlation between increased trophoblastic and endothelial AP-2γ expression in patients with preeclampsia and reduced trophoblastic invasion and migration in preeclampsia has to be discussed. Furthermore, increased AP-2γ expression may play a protective role in preeclampsia, protecting from raised blood pressure. The tendency of an enhanced trophoblastic AP-2γ expression in smokers may indicate a compensatory response to the disturbed balance between proliferation and differentiation of villi induced by smoking.