Linc-ROR confers gemcitabine resistance to pancreatic cancer cells via inducing autophagy and modulating the miR-124/PTBP1/PKM2 axis

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• 作者：Chenggang Li ; Zhiming Zhao ; Zhipeng Zhou ; Rong Liu
• 关键词：Linc ; ROR ; MiR ; 124 ; PKM2 ; Autophagy ; Gemcitabine ; Pancreatic cancer
• 刊名：Cancer Chemotherapy and Pharmacology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：78
• 期：6
• 页码：1199-1207
• 全文大小：3,199 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Cancer Research
  Pharmacology and Toxicology
  Oncology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0843
• 卷排序：78

文摘

PurposeIn this study, we investigated the regulation of linc-ROR on autophagy and gemcitabine resistance of pancreatic cancer cells and further studied the underlying involvement of the miR-124/PTBP1/PKM2 axis in this regulation.