Checkpoint kinase inhibitor AZD7762 strongly sensitises urothelial carcinoma cells to gemcitabine
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- 作者：Makoto Isono ; Michèle J. Hoffmann…
- 关键词：Gemcitabine ; AZD7762 ; Checkpoint kinase ; Urothelial carcinoma ; Bladder cancer
- 刊名：Journal of Experimental & Clinical Cancer Research
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：36
- 期：1
- 全文大小：5602KB
- 刊物主题：Oncology; Cancer Research; Immunology; Apoptosis;
- 出版者：BioMed Central
- ISSN：1756-9966
- 卷排序：36
文摘
BackgroundMore effective chemotherapies are urgently needed for bladder cancer, a major cause of morbidity and mortality worldwide. We therefore explored the efficacy of the combination of gemcitabine and AZD7762, a checkpoint kinase 1/2 (CHK1/2) inhibitor, for bladder cancer.