ANT1-mediated fatty acid-induced uncoupling as a target for improving myocellular insulin sensitivity

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• 作者：Lauren M. Sparks ; Anne Gemmink ; Esther Phielix ; Madeleen Bosma…
• 关键词：ANT1 ; Fatty acid ; induced uncoupling ; Skeletal muscle insulin sensitivity
• 刊名：Diabetologia
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：59
• 期：5
• 页码：1030-1039
• 全文大小：499 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Internal Medicine
  Metabolic Diseases
  Human Physiology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0428

文摘

Aims/hypothesis Dissipating energy via mitochondrial uncoupling has been suggested to contribute to enhanced insulin sensitivity. We hypothesised that skeletal muscle mitochondria of endurance-trained athletes have increased sensitivity for fatty acid (FA)-induced uncoupling, which is driven by the mitochondrial protein adenine nucleotide translocase 1 (ANT1).