Decoration of intramyocellular lipid droplets with PLIN5 modulates fasting-induced insulin resistance and lipotoxicity in humans
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- 作者：Anne Gemmink ; Madeleen Bosma ; Helma J. H. Kuijpers ; Joris Hoeks…
- 关键词：Fasting ; IMCL ; Lipid droplet size ; Lipotoxicity ; Perilipin 5
- 刊名：Diabetologia
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：59
- 期：5
- 页码：1040-1048
- 全文大小：501 KB
- 刊物类别：Medicine
- 刊物主题：Medicine & Public Health
Internal Medicine
Metabolic Diseases
Human Physiology - 出版者：Springer Berlin / Heidelberg
- ISSN：1432-0428
文摘
Aims/hypothesis In contrast to insulin-resistant individuals, insulin-sensitive athletes possess high intramyocellular lipid content (IMCL), good mitochondrial function and high perilipin 5 (PLIN5) levels, suggesting a role for PLIN5 in benign IMCL storage. We hypothesised a role for PLIN5 in modulating fasting-mediated insulin resistance.