The BDNF Val66Met Polymorphism Interacts with Maternal Parenting Influencing Adolescent Depressive Symptoms: Evidence of Differential Susceptibility Model
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- 作者：Leilei Zhang ; Zhi Li ; Jie Chen ; Xinying Li…
- 关键词：Adolescent depressive symptoms ; BDNF Val66Met polymorphism ; Differential susceptibility ; Gene–environment interaction ; Maternal parenting
- 刊名：Journal of Youth and Adolescence
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：45
- 期：3
- 页码：471-483
- 全文大小：538 KB
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Zhi Li (2)
Jie Chen (1)
Xinying Li (1)
Jianxin Zhang (1)
Jay Belsky (2)
1. Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Chaoyang District, Beijing, 100101, China
2. Department of Human Ecology, University of California, Davis, CA, USA - 刊物类别：Behavioral Science
- 刊物主题：Psychology
Child and School Psychology
Clinical Psychology
Health Psychology
Law and Psychology
History of Psychology
Psychology - 出版者：Springer Netherlands
- ISSN：1573-6601
文摘
Although depressive symptoms are common during adolescence, little research has examined gene–environment interaction on youth depression. This study chose the brain-derived neurotrophic factor (BDNF) gene, tested the interaction between a functional polymorphism resulting amino acid substitution of valine (Val) to methionine (Met) in the proBDNF protein at codon 66 (Val66Met), and maternal parenting on youth depressive symptoms in a sample of 780 community adolescents of Chinese Han ethnicity (aged 11–17, M = 13.6, 51.3 % females). Participants reported their depressive symptoms and perceived maternal parenting. Results indicated the BDNF Val66Met polymorphism significantly moderated the influence of maternal warmth-reasoning, but not harshness-hostility, on youth depressive symptoms. Confirmatory model evaluation indicated that the interaction effect involving warmth-reasoning conformed to the differential-susceptibility rather than diathesis-stress model of person-X-environment interaction. Thus, Val carriers experienced less depressive symptoms than Met homozygotes when mothering was more positive but more symptoms when mothering was less positive. The findings provided evidence in support of the differential susceptibility hypothesis of youth depressive symptoms and shed light on the importance of examining the gene–environment interaction from a developmental perspective. Keywords Adolescent depressive symptoms BDNF Val66Met polymorphism Differential susceptibility Gene–environment interaction Maternal parenting