Gene–Environment Interplay in Physical, Psychological, and Cognitive Domains in Mid to Late Adulthood: Is APOE a Variability Gene?

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• 作者：Chandra A. Reynolds ; Margaret Gatz ; Kaare Christensen…
• 关键词：Gene–environment interaction ; Twins ; BMI ; Depression ; Cognitive performance ; APOE ; Variability gene
• 刊名：Behavior Genetics
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：46
• 期：1
• 页码：4-19
• 全文大小：734 KB
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• 作者单位：Chandra A. Reynolds (1)
  Margaret Gatz (2) (3)
  Kaare Christensen (4) (5)
  Lene Christiansen (4)
  Anna K. Dahl Aslan (3) (6)
  Jaakko Kaprio (7)
  Tellervo Korhonen (8) (9)
  William S. Kremen (10)
  Robert Krueger (11)
  Matt McGue (11) (4)
  Jenae M. Neiderhiser (12)
  Nancy L. Pedersen (2) (3)
  for the IGEMS consortium
  
  1. Department of Psychology, University of California Riverside, 900 University Ave., Riverside, CA, 92521, USA
  2. Department of Psychology, University of Southern California, Los Angeles, CA, 90089, USA
  3. Department of Medical Epidemiology and Biostatistics, Karolinska Institute, 17177, Stockholm, Sweden
  4. Epidemiology, Biostatistics and Bio-demography, Institute of Public Health, University of Southern Denmark, 5000, Odense C, Denmark
  5. Department of Clinical Genetics and Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark
  6. Institute of Gerontology, School of Health and Welfare, Jönköping University, Jönköping, Sweden
  7. Department of Public Health & Institute for Molecular Medicine FIMM, University of Helsinki, 00014, Helsinki, Finland
  8. Department of Public Health, University of Helsinki, 00014, Helsinki, Finland
  9. Institute of Public Health and Clinical Nutrition, University of Eastern Finland, 70211, Kuopio, Finland
  10. Department of Psychiatry, University of California San Diego, La Jolla, CA, 92093, USA
  11. Department of Psychology, University of Minnesota, Minneapolis, MN, 55455, USA
  12. Department of Psychology, The Pennsylvania State University, University Park, PA, USA
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Human Genetics
  Neurosciences
  Evolutionary Biology
  
• 出版者：Springer Netherlands
• ISSN：1573-3297

文摘

Despite emerging interest in gene–environment interaction (GxE) effects, there is a dearth of studies evaluating its potential relevance apart from specific hypothesized environments and biometrical variance trends. Using a monozygotic within-pair approach, we evaluated evidence of G×E for body mass index (BMI), depressive symptoms, and cognition (verbal, spatial, attention, working memory, perceptual speed) in twin studies from four countries. We also evaluated whether APOE is a ‘variability gene’ across these measures and whether it partly represents the ‘G’ in G×E effects. In all three domains, G×E effects were pervasive across country and gender, with small-to-moderate effects. Age-cohort trends were generally stable for BMI and depressive symptoms; however, they were variable—with both increasing and decreasing age-cohort trends—for different cognitive measures. Results also suggested that APOE may represent a ‘variability gene’ for depressive symptoms and spatial reasoning, but not for BMI or other cognitive measures. Hence, additional genes are salient beyond APOE.