Gene–Environment Interaction of the Oxytocin Receptor Gene Polymorphism (rs53576) and Unresolved Attachment Status Predict Depersonalization Symptoms: An Exploratory Study

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• 作者：Iris Reiner ; Helge Frieling ; Manfred Beutel ; Matthias Michal
• 关键词：Depersonalization ; Unresolved attachment status ; Oxytocin receptor gene ; AAI
• 刊名：Psychological Studies
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：61
• 期：4
• 页码：295-300
• 全文大小：
• 刊物主题：Psychology, general; General Psychology; Personality and Social Psychology;
• 出版者：Springer India
• ISSN：0974-9861
• 卷排序：61

文摘

Depersonalization (DP), or feelings of detachment from one’s self or one’s surroundings (i.e., derealization, DR), is considered a maladaptive stress response, frequently occurring in anxiety disorders, depression or as a primary disorder. However, the pathogenesis of DP/DR symptoms is little understood. The present study aimed to elucidate the influence of unresolved attachment status and the oxytocin receptor gene (OXTR) rs53576 polymorphism on DP/DR symptoms. The study sample consisted of 84 women, including 43 depressed patients and 41 control subjects, aged 19–52. DP/DR symptoms were measured with the Cambridge Depersonalization Scale; unresolved attachment status was assessed with the Adult Attachment Interview. OXTR rs53576 genotypes were obtained from blood samples. We found a highly significant gene–environment interaction: Individuals with unresolved attachment status were significantly more depersonalized when they carried the GG-allele than A-allele carriers than not unresolved subjects. There was no statistically significant main influence of OXTR genotypes or unresolved attachment status on DP/DR symptoms. We suggest that the GG-allele and unresolved attachment status might be considered as risk factors in the etiology of DP/DR symptoms. Replication is needed in larger samples including male subjects.