Mast cells in a murine lung ischemia-reperfusion model of primary graft dysfunction

详细信息    查看全文

• 作者：John R Greenland (1) (2)
  Xiang Xu (1) (2)
  David M Sayah (3)
  Feng Chun Liu (2)
  Kirk D Jones (4)
  Mark R Looney (2)
  George H Caughey (1) (2) (5)
  
  1. Medical Service ; VA Medical Center ; San Francisco ; CA ; USA
  2. Department of Medicine ; University of California ; San Francisco ; CA ; USA
  3. Department of Medicine ; University of California ; Los Angeles ; CA ; USA
  4. Department of Pathology ; University of California ; San Francisco ; CA ; USA
  5. Cardiovascular Research Institute ; University of California ; San Francisco ; CA ; USA
  
• 刊名：Respiratory Research
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：15
• 期：1
• 全文大小：2,031 KB
• 参考文献：1. Christie, JD, Carby, M, Bag, R, Corris, P, Hertz, M, Weill, D (2005) Report of the ISHLT working group on primary lung graft dysfunction part II: definition. A consensus statement of the international society for heart and lung transplantation. J Heart Lung Transplant 24: pp. 1454-1459 CrossRef
  2. Lee, JC, Christie, JD (2009) Primary graft dysfunction. Proc Am Thorac Soc 6: pp. 39-46 CrossRef
  3. Fisher, AJ, Donnelly, SC, Hirani, N, Haslett, C, Strieter, RM, Dark, JH, Corris, PA (2001) Elevated levels of interleukin-8 in donor lungs is associated with early graft failure after lung transplantation. Am J Respir Crit Care Med 163: pp. 259-265
  4. Calfee, CS, Budev, MM, Matthay, MA, Church, G, Brady, S, Uchida, T, Ishizaka, A, Lara, A, Ranes, JL, Camp, MM, Arroliga, AC (2007) Plasma receptor for advanced glycation end-products predicts duration of ICU stay and mechanical ventilation in patients after lung transplantation. J Heart Lung Transplant 26: pp. 675-680 CrossRef
  5. Krenn, K, Klepetko, W, Taghavi, S, Lang, G, Schneider, B, Aharinejad, S (2007) Recipient vascular endothelial growth factor serum levels predict primary lung graft dysfunction. Am J Transplant 7: pp. 700-706 CrossRef
  6. Abonia, JP, Friend, DS, Austen, WG, Moore, FD, Carroll, MC, Chan, R, Afnan, J, Humbles, A, Gerard, C, Knight, P, Kanaoka, Y, Yasuda, S, Morokawa, N, Austen, KF, Stevens, RL, Gurish, MF (2005) Mast cell protease 5 mediates ischemia-reperfusion injury of mouse skeletal muscle. J Immunol 174: pp. 7285-7291 CrossRef
  7. Bhattacharya, K, Farwell, K, Huang, M, Kempuraj, D, Donelan, J, Papaliodis, D, Vasiadi, M, Theoharides, TC (2007) Mast cell deficient W/Wv mice have lower serum IL-6 and less cardiac tissue necrosis than their normal littermates following myocardial ischemia-reperfusion. Int J Immunopathol Pharmacol 20: pp. 69-74
  8. Singh, M, Saini, HK (2003) Resident cardiac mast cells and ischemia-reperfusion injury. J Cardiovasc Pharmacol Therapeut 8: pp. 135-148 CrossRef
  9. Yousem, SA (1997) The potential role of mast cells in lung allograft rejection. Hum Pathol 28: pp. 179-182 CrossRef
  10. Buvry, A, Garbarg, M, Dimitriadou, V, Rouleau, A, Newlands, GF, Tavakoli, R, Poaty, V, Lockhart, A, Schwartz, JC, Frossard, N (1996) Phenotypic and quantitative changes in mast cells after syngeneic unilateral lung transplantation in the rat. Clin Sci (Lond) 91: pp. 319-327
  11. Xu, X, Golden, JA, Dolganov, G, Jones, KD, Donnelly, S, Weaver, T, Caughey, GH (2005) Transcript signatures of lymphocytic bronchitis in lung allograft biopsy specimens. J Heart Lung Transplant 24: pp. 1055-1066 CrossRef
  12. Cruz, AC, Hall, TS, Jones, KD, Edwards, ST, Fang, KC (2004) Induction of mast cell activation and CC chemokine responses in remodeling tracheal allografts. Am J Respir Cell Mol Biol 31: pp. 154-161 CrossRef
  13. Su, M, Chi, EY, Bishop, MJ, Henderson, WR (1993) Lung mast cells increase in number and degranulate during pulmonary artery occlusion/reperfusion injury in dogs. Am Rev Respir Dis 147: pp. 448-456
  14. Vural, KM, Liao, H, Oz, MC, Pinsky, DJ (2000) Effects of mast cell membrane stabilizing agents in a rat lung ischemia-reperfusion model. Ann Thorac Surg 69: pp. 228-232 CrossRef
  15. Gilles, S, Zahler, S, Welsch, U, Sommerhoff, CP, Becker, BF (2003) Release of TNF-alpha during myocardial reperfusion depends on oxidative stress and is prevented by mast cell stabilizers. Cardiovasc Res 60: pp. 608-616 CrossRef
  16. Malaviya, R, Ikeda, T, Ross, E, Abraham, SN (1996) Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-alpha. Nature 381: pp. 77-80 CrossRef
  17. Huang, C, Friend, DS, Qiu, WT, Wong, GW, Morales, G, Hunt, J, Stevens, RL (1998) Induction of a selective and persistent extravasation of neutrophils into the peritoneal cavity by tryptase mouse mast cell protease 6. J Immunol 160: pp. 1910-1919
  18. Huang, C, Sanctis, GT, O鈥橞rien, PJ, Mizgerd, JP, Friend, DS, Drazen, JM, Brass, LF, Stevens, RL (2001) Evaluation of the substrate specificity of human mast cell tryptase beta I and demonstration of its importance in bacterial infections of the lung. J Biol Chem 276: pp. 26276-26284 CrossRef
  19. Mallen-St Clair, J, Pham, CT, Villalta, SA, Caughey, GH, Wolters, PJ (2004) Mast cell dipeptidyl peptidase I mediates survival from sepsis. J Clin Invest 113: pp. 628-634 CrossRef
  20. Neely, CF, Keith, IM (1995) A1 adenosine receptor antagonists block ischemia-reperfusion injury of the lung. Am J Physiol 268: pp. L1036-L1046
  21. Auchampach, JA, Jin, X, Wan, TC, Caughey, GH, Linden, J (1997) Canine mast cell adenosine receptors: cloning and expression of the A3 receptor and evidence that degranulation is mediated by the A2B receptor. Mol Pharmacol 52: pp. 846-860 CrossRef
  22. Ferrero, ME (2011) Purinoceptors in inflammation: potential as anti-inflammatory therapeutic targets. Front Biosci (Landmark Ed) 16: pp. 2172-2186 CrossRef
  23. Wolters, PJ, Mallen-St Clair, J, Lewis, CC, Villalta, SA, Baluk, P, Erle, DJ, Caughey, GH (2005) Tissue-selective mast cell reconstitution and differential lung gene expression in mast cell-deficient Kit(W-sh)/Kit(W-sh) sash mice. Clin Exp Allergy 35: pp. 82-88 CrossRef
  24. Grimbaldeston, MA, Chen, CC, Piliponsky, AM, Tsai, M, Tam, SY, Galli, SJ (2005) Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo. Am J Pathol 167: pp. 835-848 CrossRef
  25. Cyphert, JM, Kovarova, M, Koller, BH (2011) Unique populations of lung mast cells are required for antigen-mediated bronchoconstriction. Clin Exp Allergy 41: pp. 260-269 CrossRef
  26. Xu, X, Zhang, D, Zhang, H, Wolters, PJ, Killeen, NP, Sullivan, BM, Locksley, RM, Lowell, CA, Caughey, GH (2006) Neutrophil histamine contributes to inflammation in mycoplasma pneumonia. J Exp Med 203: pp. 2907-2917 CrossRef
  27. Gersch, C, Dewald, O, Zoerlein, M, Michael, LH, Entman, ML, Frangogiannis, NG (2002) Mast cells and macrophages in normal C57/BL/6 mice. Histochem Cell Biol 118: pp. 41-49
  28. Craig, SS, DeBlois, G, Schwartz, LB (1986) Mast cells in human keloid, small intestine, and lung by an immunoperoxidase technique using a murine monoclonal antibody against tryptase. Am J Pathol 124: pp. 427-435
  29. Looney, MR, Su, X, Ziffle, JA, Lowell, CA, Matthay, MA (2006) Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury. J Clin Invest 116: pp. 1615-1623 CrossRef
  30. Pipkorn, U, Karlsson, G, Enerback, L (1988) Phenotypic expression of proteoglycan in mast cells of the human nasal mucosa. Histochem J 20: pp. 519-525 CrossRef
  31. Wingren, U, Enerback, L (1983) Mucosal mast cells of the rat intestine: a re-evaluation of fixation and staining properties, with special reference to protein blocking and solubility of the granular glycosaminoglycan. Histochem J 15: pp. 571-582 CrossRef
  32. Nigrovic, PA, Gray, DH, Jones, T, Hallgren, J, Kuo, FC, Chaletzky, B, Gurish, M, Mathis, D, Benoist, C, Lee, DM (2008) Genetic inversion in mast cell-deficient (Wsh) mice interrupts corin and manifests as hematopoietic and cardiac aberrancy. Am J Pathol 173: pp. 1693-1701 CrossRef
  33. Looney, MR, Nguyen, JX, Hu, Y, Ziffle, JA, Lowell, CA, Matthay, MA (2009) Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury. J Clin Invest 119: pp. 3450-3461
  34. Walczak-Drzewiecka, A, Ratajewski, M, Wagner, W, Dastych, J (2008) HIF-1alpha is up-regulated in activated mast cells by a process that involves calcineurin and NFAT. J Immunol 181: pp. 1665-1672 CrossRef
  35. Gulliksson, M, Carvalho, RF, Ulleras, E, Nilsson, G (2010) Mast cell survival and mediator secretion in response to hypoxia. PLoS One 5: pp. e12360 CrossRef
  36. Perrot, M, Liu, M, Waddell, TK, Keshavjee, S (2003) Ischemia-reperfusion-induced lung injury. Am J Respir Crit Care Med 167: pp. 490-511
  37. Alard, P, Kurimoto, I, Niizeki, H, Doherty, JM, Streilein, JW (2001) Hapten-specific tolerance induced by acute, low-dose ultraviolet B radiation of skin requires mast cell degranulation. Eur J Immunol 31: pp. 1736-1746 CrossRef
  38. Lu, LF, Lind, EF, Gondek, DC, Bennett, KA, Gleeson, MW, Pino-Lagos, K, Scott, ZA, Coyle, AJ, Reed, JL, Snick, J, Strom, TB, Zheng, XX, Noelle, RJ (2006) Mast cells are essential intermediaries in regulatory T-cell tolerance. Nature 442: pp. 997-1002 CrossRef
  39. Vries, VC, Elgueta, R, Lee, DM, Noelle, RJ (2010) Mast cell protease 6 is required for allograft tolerance. Transplant Proc 42: pp. 2759-2762 CrossRef
  40. Itoh, S, Nakae, S, Velotta, JB, Kosuge, H, Connolly, A, Tsai, M, Adachi, H, Galli, SJ, Robbins, RC, Fischbein, MP (2010) The role of recipient mast cells in acute and chronic cardiac allograft rejection in C57BL/6-KitW-sh/W-sh mice. J Heart Lung Transplant 29: pp. 401-409 CrossRef
  41. Warnecke, G, Sommer, SP, Gohrbandt, B, Fischer, S, Hohlfeld, JM, Niedermeyer, J, Haverich, A, Struber, M (2004) Warm or cold ischemia in animal models of lung ischemia-reperfusion injury: is there a difference?. Thorac Cardiovasc Surg 52: pp. 174-179 CrossRef
  42. Seghaye, MC, Duchateau, J, Grabitz, RG, Mertes, J, Marcus, C, Buro, K, Messmer, BJ, Bernuth, G (1996) Histamine liberation related to cardiopulmonary bypass in children: possible relation to transient postoperative arrhythmias. J Thorac Cardiovasc Surg 111: pp. 971-981 CrossRef
  
• 刊物主题：Pneumology/Respiratory System;
• 出版者：BioMed Central
• ISSN：1465-9921

文摘

Primary graft dysfunction (PGD), as characterized by pulmonary infiltrates and high oxygen requirements shortly after reperfusion, is the major cause of early morbidity and mortality after lung transplantation. Donor, recipient and allograft-handling factors are thought to contribute, although new insights regarding pathogenesis are needed to guide approaches to prevention and therapy. Mast cells have been implicated in ischemic tissue injury in other model systems and in allograft rejection, leading to the hypothesis that mast cell degranulation contributes to lung injury following reperfusion injury. We tested this hypothesis in a mouse model of PGD involving reversible disruption of blood flow to one lung. Metrics of injury included albumin permeability, plasma extravasation, lung histopathology, and mast cell degranulation. Responses were assessed in wild-type (Kit +/+ ) and mast cell-deficient (Kit W-sh/W-sh ) mice. Because mouse lungs have few mast cells compared with human lungs, we also tested responses in mice with lung mastocytosis generated by injecting bone marrow-derived cultured mast cells (BMCMC). We found that ischemic lung responses of mast cell-deficient Kit W-sh/W-sh mice did not differ from those of Kit +/+ mice, even after priming for injury using LPS. Degranulated mast cells were more abundant in ischemic than in non-ischemic BMCMC-injected Kit W-sh/W-sh lungs. However, lung injury in BMCMC-injected Kit W-sh/W-sh and Kit +/+ mice did not differ in globally mast cell-deficient, uninjected Kit W-sh/W-sh mice or in wild-type Kit +/+ mice relatively deficient in lung mast cells. These findings predict that mast cells, although activated in lungs injured by ischemia and reperfusion, are not necessary for the development of PGD.