MRI Tracking of Macrophages Labeled with Glucan Particles Entrapping a Water Insoluble Paramagnetic Gd-Based Agent

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• 作者：Sara Figueiredo (1) (4) (5)
  Juan Carlos Cutrin (1) (2)
  Silvia Rizzitelli (1)
  Elisa De Luca (1)
  Jo?o Nuno Moreira (3) (5)
  Carlos F. G. C. Geraldes (4) (5) (6)
  Silvio Aime (1)
  Enzo Terreno (1)
  
• 关键词：MRI ; Gadolinium ; Paramagnetic MRI agents ; Glucan particles ; Cell tracking
• 刊名：Molecular Imaging and Biology
• 出版年：2013
• 出版时间：June 2013
• 年：2013
• 卷：15
• 期：3
• 页码：307-315
• 全文大小：396KB
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• 作者单位：Sara Figueiredo (1) (4) (5)
  Juan Carlos Cutrin (1) (2)
  Silvia Rizzitelli (1)
  Elisa De Luca (1)
  Jo?o Nuno Moreira (3) (5)
  Carlos F. G. C. Geraldes (4) (5) (6)
  Silvio Aime (1)
  Enzo Terreno (1)
  
  1. Department of Molecular Biotechnology and Health Sciences and Molecular and Preclinical Imaging Centers, University of Turin, Turin, Italy
  4. Department of Life Sciences, Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal
  5. CNC-Center of Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal
  2. ININCA (UBA-CONICET), Buenos Aires, Argentina
  3. FFUC-Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal
  6. Coimbra Chemistry Center, University of Coimbra, Coimbra, Portugal
  

文摘

Purpose This study is aimed at demonstrating the in vivo potential of Gd(III)-loaded glucan particles (Gd-GPs) as magnetic resonance imaging (MRI)-positive agents for labeling and tracking phagocytic cells. Procedure GPs were obtained from Saccharomyces cerevisae and loaded with the water-insoluble complex Gd-DOTAMA(C18)2. The uptake kinetics of Gd-GPs by murine macrophages was studied in vitro and the internalization mechanism was assessed by competition assays. The in vivo performance of Gd-GPs was tested at 7.05?T on a mouse model of acute liver inflammation. Results The minimum number of Gd-GPs-labeled J774.A1 macrophages detected in vitro by MRI was ca. 300 cells/μl of agar, which is the lowest number ever reported for cells labeled with a positive T1 agent. Intravenous injection of macrophages labeled with Gd-GPs in a mouse model of liver inflammation enabled the MRI visualization of the cellular infiltration in the diseased area. Conclusions Gd-GPs represent a promising platform for tracking macrophages by MRI as a T1 alternative to the golden standard T2-based iron oxide particles.