The impact of small kidneys

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• 作者：Douglas G. Matsell ; Dan Cojocaru ; Eli W. Matsell ; Allison A. Eddy
• 关键词：Renal hypodysplasia ; Pediatric ; Outcomes ; End ; stage renal disease
• 刊名：Pediatric Nephrology
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：30
• 期：9
• 页码：1501-1509
• 全文大小：463 KB
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• 作者单位：Douglas G. Matsell (1) (2) (3) (4)
  Dan Cojocaru (1)
  Eli W. Matsell (1)
  Allison A. Eddy (1) (2) (3) (4)
  
  1. Department of Pediatrics, British Columbia Children’s Hospital, Vancouver, BC, Canada
  2. Child and Family Research Institute, Vancouver, BC, Canada
  3. British Columbia Provincial Renal Agency, Vancouver, BC, Canada
  4. Division of Nephrology, British Columbia Children’s Hospital, 4480 Oak Street, Room K4-150, Vancouver, BC, Canada, V6H 3V4
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Pediatrics
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-198X

文摘

Background Small kidneys due to renal hypodysplasia (RHD) result from a decrease in nephron number. The objectives of this study were to identify clinical variables that determine long-term renal outcome in children with RHD and to define the role of kidney size as a predictor of developing end-stage renal disease (ESRD). Methods This was a single-center retrospective cohort analysis. The primary outcome was development of ESRD. We identified 202 RHD cases, with 25 (12?%) reaching ESRD at mean age of 8.9 (±6.6) years. Results Children with RHD with a known genetic syndrome had the smallest kidneys while those with posterior urethral valves (PUV) had the largest kidneys at diagnosis. Cases with bilateral RHD were most likely to develop ESRD. Younger gestational age (OR 0.8, CI 0.69-.99, p--.05), smaller kidney size at diagnosis (OR 0.13, CI 0.03-.47, p--.002), lower best-estimated glomerular filtration rate (eGFR) (OR 0.74, CI 0.58-.93, p--.01), proteinuria (OR 1.03, CI 1.01-.05, p-lt;-.001) and high blood pressure (OR 1.02, CI 1.01-.04, p--.01) were associated with development of ESRD, while kidney size at diagnosis was independently associated with ESRD (HR 0.03, CI 0.01-.72, p--.043). Conclusions In children with RHD, kidney size at diagnosis predicts the likelihood of developing ESRD.