参考文献:1. Wilkinson IB, Franklin SS, Cockcroft JR (2004) Nitric oxide and the regulation of large artery stiffness: from physiology to pharmacology. Hypertension 44:112–116 2. McEniery CM, Qasem A, Schmitt M, Avolio AP, Cockcroft JR, Wilkinson IB (2003) Endothelin-1 regulates arterial pulse wave velocity in vivo. J Am Coll Cardiol 42:1975–1981 3. Wallace SM, Yasmin McEniery CM et al (2007) Isolated systolic hypertension is characterized by increased aortic stiffness and endothelial dysfunction. Hypertension 50:228–233 4. Gunarathne A, Patel JV, Kausar S, Gammon B, Hughes EA, Lip GY (2009) Glycemic status underlies increased arterial stiffness and impaired endothelial function in migrant South Asian stroke survivors compared to European Caucasians: pathophysiological insights from the West Birmingham Stroke Project. Stroke 40:2298–2306 5. Ravikumar R, Deepa R, Shanthirani C, Mohan V (2002) Comparison of carotid intima-media thickness, arterial stiffness, and brachial artery flow mediated dilatation in diabetic and nondiabetic subjects (The Chennai Urban Population Study [CUPS-9]). Am J Cardiol 90:702–707 6. Jadhav UM, Kadam NN (2005) Non-invasive assessment of arterial stiffness by pulse-wave velocity correlates with endothelial dysfunction. Indian Heart J 57:226–232 7. Kobayashi K, Akishita M, Yu W, Hashimoto M, Ohni M, Toba K (2004) Interrelationship between non-invasive measurements of atherosclerosis: flow-mediated dilation of brachial artery, carotid intima-media thickness and pulse wave velocity. Atherosclerosis 173:13–18 8. Nigam A, Mitchell GF, Lambert J, Tardif JC (2003) Relation between conduit vessel stiffness (assessed by tonometry) and endothelial function (assessed by flow-mediated dilatation) in patients with and without coronary heart disease. Am J Cardiol 92:395–399 9. Kopec G, Podolec P, Podolec J, Rubis P, Zmudka K, Tracz W (2009) Atherosclerosis progression affects the relationship between endothelial function and aortic stiffness. Atherosclerosis 204:250–254 10. McEniery CM, Wallace S, Mackenzie IS et al (2006) Endothelial function is associated with pulse pressure, pulse wave velocity, and augmentation index in healthy humans. Hypertension 48:602–608 11. Koivistoinen T, Virtanen M, Hutri-Kahonen N et al (2011) Arterial pulse wave velocity in relation to carotid intima-media thickness, brachial flow-mediated dilation and carotid artery distensibility: The Cardiovascular Risk in Young Finns Study and the Health 2000 Survey. Atherosclerosis 220:387–393 12. Wilson AM, O'Neal D, Nelson CL, Prior DL, Best JD, Jenkins AJ (2004) Comparison of arterial assessments in low and high vascular disease risk groups. Am J Hypertens 17:285–291 13. Lonati C, Morganti A, Comarella L, Mancia G, Zanchetti A (2008) Prevalence of type 2 diabetes among patients with hypertension under the care of 30 Italian clinics of hypertension: results of the (Iper)tensione and (dia)bete study. J Hypertens 26:1801–1808 14. Stehouwer CD, Henry RM, Ferreira I (2008) Arterial stiffness in diabetes and the metabolic syndrome: a pathway to cardiovascular disease. Diabetologia 51:527–539 15. Taddei S, Virdis A, Ghiadoni L, Sudano I, Salvetti A (2001) Endothelial dysfunction in hypertension. J Cardiovasc Pharmacol 38(Suppl 2):S11–S14 16. Laurent S, Boutouyrie P, Asmar R et al (2001) Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 37:1236–1241 17. Tedesco MA, Natale F, Di Salvo G, Caputo S, Capasso M, Calabro R (2004) Effects of coexisting hypertension and type II diabetes mellitus on arterial stiffness. J Hum Hypertens 18:469–473 18. Ghiadoni L, Penno G, Giannarelli C et al (2008) Metabolic syndrome and vascular alterations in normotensive subjects at risk of diabetes mellitus. Hypertension 51:440–445 19. Mancia G, de Backer G, Dominiczak A et al (2007) 2007 Guidelines for the management of arterial hypertension: The task force for the management of arterial hypertension of the European society of hypertension (ESH) and of the European society of cardiology (ESC). J Hypertens 25:1105–1187 20. Laurent S, Cockcroft J, van Bortel L et al (2006) Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J 27:2588–2605 21. Plantinga Y, Ghiadoni L, Magagna A et al (2007) Supplementation with vitamins C and E improves arterial stiffness and endothelial function in essential hypertensive patients. Am J Hypertens 20:392–397 22. Pyke KE, Dwyer EM, Tschakovsky ME (2004) Impact of controlling shear rate on flow-mediated dilation responses in the brachial artery of humans. J Appl Physiol 97:499–508 23. Thijssen DH, Black MA, Pyke KE et al (2011) Assessment of flow-mediated dilation in humans: a methodological and physiological guideline. Am J Physiol Heart Circ Physiol 300:H2–H12 24. Mitchell GF, Parise H, Vita JA et al (2004) Local shear stress and brachial artery flow-mediated dilation: the Framingham Heart Study. Hypertension 44:134–139 25. Grundy SM, Cleeman JI, Daniels SR et al (2005) Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 112:2735–2752 26. Schofield I, Malik R, Izzard A, Austin C, Heagerty A (2002) Vascular structural and functional changes in type 2 diabetes mellitus: evidence for the roles of abnormal myogenic responsiveness and dyslipidemia. Circulation 106:3037–3043 27. Rizzoni D, Porteri E, Guelfi D et al (2001) Endothelial dysfunction in small resistance arteries of patients with non-insulin-dependent diabetes mellitus. J Hypertens 19:913–919 28. Deanfield J, Donald A, Ferri C et al (2005) Endothelial function and dysfunction. Part I: Methodological issues for assessment in the different vascular beds: a statement by the Working Group on Endothelin and Endothelial Factors of the European Society of Hypertension. J Hypertens 23:7–17 29. Taddei S, Virdis A, Ghiadoni L, Salvetti G, Salvetti A (2000) Endothelial dysfunction in hypertension. J Nephrol 13:205–210 30. Ghiadoni L, Bruno RM, Stea F, Virdis A, Taddei S (2009) Central blood pressure, arterial stiffness, and wave reflection: new targets of treatment in essential hypertension. Curr Hypertens Rep 11:190–196 31. Cecelja M, Chowienczyk P (2009) Dissociation of aortic pulse wave velocity with risk factors for cardiovascular disease other than hypertension: a systematic review. Hypertension 54:1328–1336 32. Virdis A, Ghiadoni L, Versari D, Giannarelli C, Salvetti A, Taddei S (2008) Endothelial function assessment in complicated hypertension. Curr Pharm Des 14:1761–1770 33. Ghiadoni L, Magagna A, Kardasz I, Taddei S, Salvetti A (2009) Fixed dose combination of perindopril and indapamide improves peripheral vascular function in essential hypertensive patients. Am J Hypertens 22:506–512 34. Taddei S, Virdis A, Ghiadoni L, Sudano I, Salvetti A (2002) Effects of antihypertensive drugs on endothelial dysfunction: clinical implications. Drugs 62:265–284 35. Thacher T, Gambillara V, Da Silva R, Montorzi G, Stergiopulos N, Silacci P (2007) Oscillatory shear stress and reduced compliance impair vascular functions. Clin Hemorheol Microcirc 37:121–130 36. Czernichow S, Bertrais S, Blacher J et al (2005) Metabolic syndrome in relation to structure and function of large arteries: a predominant effect of blood pressure. A report from the SU.VI.MAX. Vascular Study. Am J Hypertens 18:1154–1160 37. Schillaci G, Pirro M, Vaudo G et al (2005) Metabolic syndrome is associated with aortic stiffness in untreated essential hypertension. Hypertension 45:1078–1082 38. Plantinga Y, Ghiadoni L, Magagna A et al (2008) Peripheral wave reflection and endothelial function in untreated essential hypertensive patients with and without the metabolic syndrome. J Hypertens 26:1216–1222 39. Ghiadoni L, Magagna A, Versari D et al (2003) Different effect of antihypertensive drugs on conduit artery endothelial function. Hypertension 41:1281–1286 40. Pauca AL, O'Rourke MF, Kon ND (2001) Prospective evaluation of a method for estimating ascending aortic pressure from the radial artery pressure waveform. Hypertension 38:932–937 41. Verbeke F, Segers P, Heireman S, Vanholder R, Verdonck P, van Bortel LM (2005) Noninvasive assessment of local pulse pressure: importance of brachial-to-radial pressure amplification. Hypertension 46:244–248
作者单位:1. Department of Internal Medicine, University of Pisa, Via Roma 67, 56126 Pisa, Italy2. Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
刊物类别:Medicine
刊物主题:Medicine & Public Health Internal Medicine Metabolic Diseases Human Physiology
出版者:Springer Berlin / Heidelberg
ISSN:1432-0428
文摘
Aims/hypothesis Endothelium-derived factors are thought to be physiological modulators of large artery stiffness. The aim of the study was to investigate whether endothelial function could be a determinant of arterial stiffness in essential hypertensive patients, in relation with the concomitant presence of type 2 diabetes mellitus.