Associations of polymorphisms in GHRL, GHSR, and IGF1R genes with feed efficiency in chickens

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• 作者：Sihua Jin (1)
  Sirui Chen (1)
  Huifeng Li (2)
  Yue Lu (1)
  Guiyun Xu (1)
  Ning Yang (1)
  
• 关键词：Chicken ; Feed efficiency ; Polymorphisms ; GHRL ; GHSR ; IGF1R
• 刊名：Molecular Biology Reports
• 出版年：2014
• 出版时间：June 2014
• 年：2014
• 卷：41
• 期：6
• 页码：3973-3979
• 全文大小：
• 参考文献：1. Sharma P, Bottje W, Okimoto R (2008) Polymorphisms in uncoupling protein, melanocortin 3 receptor, melanocortin 4 receptor, and pro-opiomelanocortin genes and association with production traits in a commercial broiler line. Poult Sci 87:2073-086 CrossRef
  2. Tschop M, Smiley DL, Heiman ML (2000) Ghrelin induces adiposity in rodents. Nature 407:908-13 CrossRef
  3. Hayashida T, Murakami K, Mogi K, Nishihara M, Nakazato M, Mondal MS, Horii Y, Kojima M, Kangawa K, Murakami N (2001) Ghrelin in domestic animals: distribution in stomach and its possible role. Domest Anim Endocrinol 21:17-4 CrossRef
  4. Pazos Y, Casanueva FF, Camina JP (2008) Basic aspects of ghrelin action. Vitam Horm 77:89-19 CrossRef
  5. Moe HH, Shimogiri T, Kamihiraguma W, Isobe H, Kawabe K, Okamoto S, Minvielle F, Maeda Y (2007) Analysis of polymorphisms in the insulin-like growth factor 1 receptor (IGF1R) gene from Japanese quail selected for body weight. Anim Genet 38:659-61 CrossRef
  6. Fang M, Nie Q, Luo C, Zhang D, Zhang X (2007) An 8?bp indel in exon 1 of Ghrelin gene associated with chicken growth. Domest Anim Endocrinol 32:216-25 CrossRef
  7. Ukkola O, Ravussin E, Jacobson P, Snyder EE, Chagnon M, Sjostrom L, Bouchard C (2001) Mutations in the preproghrelin/ghrelin gene associated with obesity in humans. J Clin Endocrinol Metab 86:3996-999 CrossRef
  8. Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, Dhillo WS, Ghatei MA, Bloom SR (2001) Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 86:5992 CrossRef
  9. Horvath TL, Diano S, Sotonyi P, Heiman M, Tschop M (2001) Minireview: ghrelin and the regulation of energy balance-a hypothalamic perspective. Endocrinology 142:4163-169
  10. Kaiya H, Van Der Geyten S, Kojima M, Hosoda H, Kitajima Y, Matsumoto M, Geelissen S, Darras VM, Kangawa K (2002) Chicken ghrelin: purification, cDNA cloning, and biological activity. Endocrinology 143:3454-463 CrossRef
  11. Nie Q, Zeng H, Lei M, Ishag NA, Fang M, Sun B, Yang G, Zhang X (2004) Genomic organisation of the chicken ghrelin gene and its single nucleotide polymorphisms detected by denaturing high-performance liquid chromatography. Br Poult Sci 45:611-18 CrossRef
  12. Ando T, Ichimaru Y, Konjiki F, Shoji M, Komaki G (2007) Variations in the preproghrelin gene correlate with higher body mass index, fat mass, and body dissatisfaction in young Japanese women. Am J Clin Nutr 86:25-2
  13. Shuto Y, Shibasaki T, Otagiri A, Kuriyama H, Ohata H, Tamura H, Kamegai J, Sugihara H, Oikawa S, Wakabayashi I (2002) Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding, and adiposity. J Clin Invest 109:1429-436 CrossRef
  14. Davenport AP, Bonner TI, Foord SM, Harmar AJ, Neubig RR, Pin JP, Spedding M, Kojima M, Kangawa K (2005) International Union of Pharmacology. LVI. Ghrelin receptor nomenclature, distribution, and function. Pharmacol Rev 57:541-46 CrossRef
  15. Sun Y, Wang P, Zheng H, Smith RG (2004) Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor. Proc Natl Acad Sci U S A 101:4679-684 CrossRef
  16. Ueda H, Ikegami H, Kawaguchi Y, Fujisawa T, Yamato E, Shibata M, Ogihara T (1999) Genetic analysis of late-onset type 2 diabetes in a mouse model of human complex trait. Diabetes 48:1168-174 CrossRef
  17. Zhang B, Chen H, Guo Y, Zhang L, Zhao M, Lan X, Zhang C, Pan C, Hu S, Wang J, Lei C (2009) Associations of polymorphism within the GHSR gene with growth traits in Nanyang cattle. Mol Biol Rep 36:2259-263 CrossRef
  18. Tanaka M, Miyazaki T, Yamamoto I, Nakai N, Ohta Y, Tsushima N, Wakita M, Shimada K (2003) Molecular characterization of chicken growth hormone secretagogue receptor gene. Gen Comp Endocrinol 134:198-02 CrossRef
  19. Kajimoto Y, Rotwein P (1991) Structure of the chicken insulin-like growth factor I gene reveals conserved promoter elements. J Biol Chem 266:9724-731
  20. Butler AA, LeRoith D (2001) Minireview: tissue-specific versus generalized gene targeting of the igf1 and igf1r genes and their roles in insulin-like growth factor physiology. Endocrinology 142:1685-688 CrossRef
  21. Kopecny M, Stratil A, Bartenschlager H, Peelman LJ, Van Poucke M, Geldermann H (2002) Linkage and radiation hybrid mapping of the porcine IGF1R and TPM2 genes to chromosome 1. Anim Genet 33:398-00 CrossRef
  22. Denley A, Cosgrove LJ, Booker GW, Wallace JC, Forbes BE (2005) Molecular interactions of the IGF system. Cytokine Growth Factor Rev 16:421-39 CrossRef
  23. Kawashima Y, Kanzaki S, Yang F, Kinoshita T, Hanaki K, Nagaishi J, Ohtsuka Y, Hisatome I, Ninomoya H, Nanba E, Fukushima T, Takahashi S (2005) Mutation at cleavage site of insulin-like growth factor receptor in a short-stature child born with intrauterine growth retardation. J Clin Endocrinol Metab 90:4679-687 CrossRef
  24. Louvi A, Accili D, Efstratiadis A (1997) Growth-promoting interaction of IGF-II with the insulin receptor during mouse embryonic development. Dev Biol 189:33-8 CrossRef
  25. Abbott AM, Bueno R, Pedrini MT, Murray JM, Smith RJ (1992) Insulin-like growth factor I receptor gene structure. J Biol Chem 267:10759-0763
  26. Yang YW, Robbins AR, Nissley SP, Rechler MM (1991) The chick embryo fibroblast cation-independent mannose 6-phosphate receptor is functional and immunologically related to the mammalian insulin-like growth factor-II (IGF-II)/man 6-P receptor but does not bind IGF-II. Endocrinology 128:1177-189 CrossRef
  27. Barrett JC, Fry B, Maller J, Daly MJ (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21:263-65 CrossRef
  28. Ardlie KG, Kruglyak L, Seielstad M (2002) Patterns of linkage disequilibrium in the human genome. Nat Rev Genet 3:299-09 CrossRef
  29. Grunau C, Buard J, Brun ME, De Sario A (2006) Mapping of the juxtacentromeric heterochromatin-euchromatin frontier of human chromosome 21. Genome Res 16:1198-207 CrossRef
  30. Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K, Matsukura S (2001) A role for ghrelin in the central regulation of feeding. Nature 409:194-98 CrossRef
  31. Miyasaka K, Hosoya H, Sekime A, Ohta M, Amono H, Matsushita S, Suzuki K, Higuchi S, Funakoshi A (2006) Association of ghrelin receptor gene polymorphism with bulimia nervosa in a Japanese population. J Neural Transm 113:1279-285 CrossRef
  32. Fang M, Nie Q, Luo C, Zhang D, Zhang X (2010) Associations of GHSR gene polymorphisms with chicken growth and carcass traits. Mol Biol Rep 37:423-28 CrossRef
  33. Sell C, Dumenil G, Deveaud C, Miura M, Coppola D, DeAngelis T, Rubin R, Efstratiadis A, Baserga R (1994) Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts. Mol Cell Biol 14:3604-612
  34. Lei M, Peng X, Zhou M, Luo C, Nie Q, Zhang X (2008) Polymorphisms of the IGF1R gene and their genetic effects on chicken early growth and carcass traits. BMC Genet 9:70 CrossRef
  35. Leal Ade C, Canton AP, Montenegro LR, Coutinho DC, Arnhold IJ, Jorge AA (2011) Mutations in insulin-like growth factor receptor 1 gene (IGF1R) resulting in intrauterine and postnatal growth retardation. Arq Bras Endocrinol Metabol 55:541-49 CrossRef
  36. Zhou H, Mitchell AD, McMurtry JP, Ashwell CM, Lamont SJ (2005) Insulin-like growth factor-I gene polymorphism associations with growth, body composition, skeleton integrity, and metabolic traits in chickens. Poult Sci 84:212-19 CrossRef
  
• 作者单位：Sihua Jin (1)
  Sirui Chen (1)
  Huifeng Li (2)
  Yue Lu (1)
  Guiyun Xu (1)
  Ning Yang (1)
  
  1. National Engineering Laboratory for Animal Breeding and MOA Key Laboratory of Animal Genetics and Breeding, Department of Animal Genetics and Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China
  2. College of Life Science, Shanxi Agricultural University, Taigu, 030801, China
  
• ISSN：1573-4978

文摘

The ghrelin (GHRL), ghrelin receptor (GHSR), and insulin-like growth factor 1 receptor (IGF1R) genes have crucial effects on body weight (BW), body weight gain (BWG), feed intake (FI), and feed conversion ratio (FCR) in many species. However, few studies on associations of GHRL, GHSR, and IGF1R with BWG, FI, and FCR have been reported in chickens. In this study, 16 SNPs in GHRL, GHSR, and IGF1R genes were genotyped by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). The objective of this study was to examine the associations of GHRL, GHSR, and IGF1R genes polymorphisms with BW at 49?days (BW49) and 70?days (BW70) of age, BWG, FI, and FCR in the interval in two yellow meat-type populations with a total of 724 birds. The results showed that rs15675067 of GHRL was significantly associated with BW70, BWG, and FCR (P?<?0.05). For GHSR, rs16675844 had significant effects on FI and FCR (P?<?0.01), and that rs14678932 showed significant association with BWG and FI (P?<?0.05). Rs14011780 of IGF1R was strongly associated with BW49, BW70, and FCR (P?<?0.05). Furthermore, haplotypes based on three SNPs of rs14986828, rs15675067, and rs15675065 in GHRL were significantly associated with BW70 and FCR (P?<?0.05). Meanwhile, a three-SNP haplotype comprising rs14011783, rs14011780, and rs14011776 in IGF1R showed significant effects on BW49, BW70, and FCR (P?<?0.05). Therefore, it was concluded that the identified SNPs and analyzed haplotypes in this study might be useful for broiler breeding programs.