Merkel cell carcinoma: a systematic review of ENT presentations

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• 作者：Federico Maria Gioacchini (1)
  Valentina Postacchini (3)
  Oriana Simonetti (3)
  Annamaria Offidani (3)
  Giuseppe Magliulo (4)
  Massimo Re (2)
  
• 关键词：Merkel cell carcinoma ; Pinna ; Nose ; ENT mucosal sites ; Parotid gland
• 刊名：European Archives of Oto-Rhino-Laryngology
• 出版年：2013
• 出版时间：August 2013
• 年：2013
• 卷：270
• 期：8
• 页码：2191-2199
• 全文大小：187KB
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• 作者单位：Federico Maria Gioacchini (1)
  Valentina Postacchini (3)
  Oriana Simonetti (3)
  Annamaria Offidani (3)
  Giuseppe Magliulo (4)
  Massimo Re (2)
  
  1. Otolaryngology Department, University Hospital of Modena, Via del Pozzo 71, 41100, Modena, Italy
  3. Dermatology Department, Marche Polytechnic University, Ancona, Italy
  4. Department of Otorhinolaryngology “G. Ferreri- “La Sapienza-University, Rome, Italy
  2. Otorhinolaryngology Department, Marche Polytechnic University, Ancona, Italy
  

文摘

The aim of this study was to perform a systematic literature review of Merkel cell carcinomas (MCCs) originating exclusively in the ear, nose and throat (ENT) district. An appropriate string was run on PubMed to retrieve articles dealing with ENT presentations of MCC. A double cross-check was performed on citations and full-text articles found using the selected inclusion and exclusion criteria. In total, 43 articles were finally included in the study, describing 51 cases of MCC involving the ENT region: 22/51 (43?%) cases involving the ear; 20/51 (39?%) cases involving the mucosal sites; 9/51 (18?%) cases involving other ENT regions. Patients with mucosal site involvement showed a higher mortality rate from the disease (45?%) in comparison with the other two groups, especially when compared with those patients having primary involvement of the ear (22?%). The ENT specialist should suspect and consider MCC, especially in elderly patients presenting with a suspicious lesion of the auricular pavilion, so as to avoid misdiagnosis and delayed treatments.