Efficacy of Serum Prealbumin and CRP Levels as Monitoring Tools for Patients with Fascial Space Infections of Odontogenic Origin: A Clinicobiochemical Study

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• 作者：Ashish Sharma (1)
  Girish Giraddi (2)
  Gokkula Krishnan (1)
  Ashish Kumar Shahi (1)
  
• 关键词：Prealbumin ; C ; reactive protein ; Odontogenic space infection
• 刊名：Journal of Maxillofacial and Oral Surgery
• 出版年：2014
• 出版时间：March 2014
• 年：2014
• 卷：13
• 期：1
• 页码：1-9
• 全文大小：957 KB
• 参考文献：1. Ylyjoki S, Suuronen R, Somer HJ, Meurman JH, Lindqvist C (2001) Differences between patients with or without the need for intensive care due to severe odontogenic infections. J Oral Maxillofac Surg 59:867-72 CrossRef
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• 作者单位：Ashish Sharma (1)
  Girish Giraddi (2)
  Gokkula Krishnan (1)
  Ashish Kumar Shahi (1)
  
  1. Department of OMFS, Kothiwal Dental College and Research Centre, Moradabad, India
  2. Department of OMFS, Government Dental College, Bangalore, India
  
• ISSN：0974-942X

文摘

Objectives Study includes 20 patients with diagnosis of fascial space infections of odontogenic origin to assess efficacy of serum prealbumin and CRP levels as monitoring tools for determining severity of infections, nutritional status, hospital stay and efficacy of treatment. Methods Blood samples taken on day 0, 4, and 8 for measuring serum levels of markers. Simultaneously clinical parameters like swelling size, pain etc., were also recorded on day 0, 4, and 8 and appropriate treatment given to each patient. Correlation between markers and parameters was found using regression and paired t test. Results Statistical analysis found strong correlation between laboratory values of markers and parameters used to measure severity of infection also. Prealbumin and crp are significant markers for hospital stay (p?<?0.01). Prealbumin also found to be a sensitive indicator of nutritional status (p?<?0.001). Interpretation and Conclusion Prospective analysis indicates prealbumin and crp are effective markers for determining severity of infection, treatment efficacy and hospital stay. Prealbumin is also sensitive marker for nutritional status. Duration of antibiotic usage, intensive unit care, use of nutritional supplements becomes more rationale. Markers also make treatment cost effective and help protecting patients from side effects of excess drug usage.