The SYSCILIA gold standard (SCGSv1) of known ciliary components and its applications within a systems biology consortium

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• 作者：Teunis JP van Dam (1)
  Gabrielle Wheway (2)
  Gisela G Slaats (3)
  Martijn A Huynen (1)
  Rachel H Giles (3)
  
• 刊名：Cilia
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：2
• 期：1
• 全文大小：177KB
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• 作者单位：Teunis JP van Dam (1)
  Gabrielle Wheway (2)
  Gisela G Slaats (3)
  Martijn A Huynen (1)
  Rachel H Giles (3)
  
  1. Centre for Molecular and Biomolecular Informatics, Radboud University Medical Centre, Nijmegen, 6500 HB, The Netherlands
  2. Section of Ophthalmology and Neuroscience, Leeds Institute of Molecular Medicine, Wellcome Trust Brenner Building, St James鈥檚 University Hospital, Leeds, LS9 7TF, UK
  3. Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, 3508 GA, The Netherlands
  

文摘

The multinational SYSCILIA consortium aims to gain a mechanistic understanding of the cilium. We utilize multiple parallel high-throughput (HTP) initiatives to develop predictive models of relationships between complex genotypes and variable phenotypes of ciliopathies. The models generated are only as good as the wet laboratory data fed into them. It is therefore essential to orchestrate a well-annotated and high-confidence dataset to be able to assess the quality of any HTP dataset. Here, we present the inaugural SYSCILIA gold standard of known ciliary components as a public resource.