High extent of O-GlcNAcylation in breast cancer cells correlates with the levels of HAS enzymes, accumulation of hyaluronan, and poor outcome
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- 作者：Satu Tiainen ; Sanna Oikari ; Markku Tammi…
- 关键词：O ; GlcNAcylation ; Hyaluronan ; Hyaluronan synthase ; Breast cancer
- 刊名：Breast Cancer Research and Treatment
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：160
- 期：2
- 页码：237-247
- 全文大小：953 KB
- 刊物类别：Medicine
- 刊物主题：Medicine & Public Health
Oncology - 出版者：Springer Netherlands
- ISSN：1573-7217
- 卷排序：160
文摘
PurposeObesity and oversupply of glucose, e.g., due to nutritional factors may shape the tumor microenvironment favorable for tumor progression. O-GlcNAcylation, a reversible modification of intracellular proteins, influences on several cellular functions and is connected to many diseases including cancer. Glycosaminoglycan hyaluronan (HA) enhances tumor progression and in breast cancer HA accumulation associates strongly with poor outcome. In vitro studies have suggested that O-GlcNAcylation may enhance HA synthesis. The aim of this study was to investigate the correlations between O-GlcNAcylation, HA-related parameters, and disease outcome in a clinical breast cancer material consisting of 278 breast cancer cases.