Combined membranous nephropathy and crescentic glomerulonephritis with concurrent anti-glomerular basement membrane antibody and myeloperoxidase-specific anti-neutrophil cytoplasmic antibody

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• 作者：Yoichi Iwafuchi (1)
  Takashi Morita (2)
  Yuko Oyama (1)
  Akira Kamimura (1)
  Shigeru Miyazaki (3)
  Ichiei Narita (4)
  
• 关键词：Membranous nephropathy ; Crescentic glomerulonephritis ; Anti ; glomerular basement membrane antibody ; Myeloperoxidase ; specific anti ; neutrophil cytoplasmic antibody
• 刊名：CEN Case Reports
• 出版年：2013
• 出版时间：May 2013
• 年：2013
• 卷：2
• 期：1
• 页码：107-111
• 全文大小：536KB
• 参考文献：1. Schwartz MM. Combined membranous and crescentic GN. In: Jennette JC, Olson JL, Schwartz MM, Silva FG, editors. Pathology of the kidney. 6th ed. Philadelphia: Lippincott Williams & Wilkins; 2007. p. 222鈥?.
  2. Klassen J, Elwood C, Grossberg AL, Milgrom F, Montes M, Sepulveda M, Andres GA. Evolution of membranous nephropathy into anti-glomerular-basement-membrane glomerulonephritis. N Engl J Med. 1974;290:1340鈥?. CrossRef
  3. Basford AW, Lewis J, Dwyer JP, Fogo AB. Membranous nephropathy with crescents. J Am Soc Nephrol. 2011;22:1804鈥?. CrossRef
  4. Troxell ML, Saxena AB, Kambham N. Concurrent anti-glomerular basement membrane disease and membranous glomerulonephritis: a case report and literature review. Clin Nephrol. 2006;66:120鈥?.
  5. Kielstein JT, Helmchen U, Netzer K-O, Weber M, Haller H, Floege J. Conversion of Goodpasture鈥檚 syndrome into membranous glomerulonephritis. Nephrol Dial Transplant. 2001;16:2082鈥?. CrossRef
  6. Nasr SH, Said SM, Valeri AM, Stokes MB, Masani NN, D鈥橝gati VD, Markowitz GS. Membranous glomerulonephritis with ANCA-associated necrotizing and crescentic glomerulonephritis. Clin J Am Soc Nephrol. 2009;4:299鈥?08. CrossRef
  7. Rutgers A, Slot M, van Paassen P, van Breda Vriesman P, Heeringa P, Tervaert JW. Coexistence of anti-glomerular basement membrane antibodies and myeloperoxidase-ANCAs in crescentic glomerulonephritis. Am J Kidney Dis. 2005;46:253鈥?2. CrossRef
  8. Hanamura K, Tojo A, Kinugasa S, Asaba K, Onozato ML, Uozaki H, Fukayama M, Fujita T. Detection of myeloperoxidase in membranous nephropathy-like deposits in patients with anti-neutrophil cytoplasmic antibody-associated glomerulonephritis. Hum Pathol. 2011;42:649鈥?8. CrossRef
  9. Ogawa N, Yano S, Yamane Y, Nishiki M, Yamaguchi T, Tsukamoto T, Muso E, Sugimoto T. MPO-ANCA-positive IgA nephropathy successfully treated with tonsillectomy. Clin Exp Nephrol. 2007;11:326鈥?1. CrossRef
  10. Nasr SH, D鈥橝gati VD, Park HR, Sterman PL, Goyzueta JD, Dressler RM, Hazlett SM, Pursell RN, Caputo C, Markowitz GS. Necrotizing and crescentic lupus nephritis with antineutrophil cytoplasmic antibody seropositivity. Clin J Am Soc Nephrol. 2008;3:682鈥?0. CrossRef
  11. Surindran S, Ayalon R, Hasan N, Beck LH Jr, Salant DJ, Barisoni L, Skolnik EY, Beara-Lasic L. Coexistence of ANCA-associated glomerulonephritis and anti-phospholipase A2 receptor antibody-positive membranous nephropathy. Clin Kidney J. 2012;5:162鈥?.
  12. Slot MC, Links TP, Stegeman CA, Tervaert JW. Occurrence of antineutrophil cytoplasmic antibodies and associated vasculitis in patients with hyperthyroidism treated with antithyroid drugs: a long-term followup study. Arthritis Rheum. 2005;53:108鈥?3. CrossRef
  13. Kain R, Exner M, Brandes R, Ziebermayr R, Cunningham D, Alderson CA, Davidovits A, Raab I, Jahn R, Ashour O, Spitzauer S, Sunder-Plassmann G, Fukuda M, Klemm P, Rees AJ, Kerjaschki D. Molecular mimicry in pauci-immune focal necrotizing glomerulonephritis. Nat Med. 2008;14:1088鈥?6. CrossRef
  14. Meisels IS, Stillman IE, Kuhlik AB. Anti-glomerular basement membrane disease and dual positivity for antineutrophil cytoplasmic antibody in a patient with membranous nephropathy. Am J Kidney Dis. 1998;32:646鈥?. CrossRef
  15. Etter C, Gaspert A, Regenass S, W眉thrich RP, Kistler T, Kain R, Cohen CD. Anti-hLAMP2-antibodies and dual positivity for anti-GBM and MPO-ANCA in a patient with relapsing pulmonary-renal syndrome. BMC Nephrol. 2011;12:26. CrossRef
  
• 作者单位：Yoichi Iwafuchi (1)
  Takashi Morita (2)
  Yuko Oyama (1)
  Akira Kamimura (1)
  Shigeru Miyazaki (3)
  Ichiei Narita (4)
  
  1. Department of Internal Medicine, Koseiren Sanjo General Hospital, 5-1-62 Tsukanome, Sanjo, 955-0055, Japan
  2. Department of Pathology, Shinrakuen Hospital, 3-3-11 Shindoriminami Nishi-ku, Niigata, 950-2087, Japan
  3. Department of Internal Medicine, Kidney Center, Shinrakuen Hospital, 3-3-11 Shindoriminami, Nishi-ku, Niigata, 950-2087, Japan
  4. Clinical Nephrology and Rheumatology, Department of Medicine II, Niigata University Graduate School of Medical and Dental Sciences, 1-754 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan
  

文摘

We report a case of a 71-year-old man with rapidly progressive nephritic syndrome and dual positivity for anti-glomerular basement membrane antibody and myeloperoxidase-specific anti-neutrophil cytoplasmic antibody. Renal biopsy revealed crescentic, mainly cellular, glomerulonephritis with granulomatous lesions, and advanced membranous changes. Membranous nephropathy had apparently existed for an extended period before the development of crescentic glomerulonephritis. In some studies reporting the simultaneous occurrence of both diseases, membranous nephropathy might be followed by crescentic glomerulonephritis, presumably from a histological point of view. Although we cannot prove a causal relationship between the two diseases, we caution that precise observations, especially histological, are necessary in similar cases.