ANCA positive crescentic glomerulonephritis outcome in a Central East European cohort: a retrospective study
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- 作者：Iuliana Andreiana ; Simona Stancu ; Andreea Avram ; Ludmila Taran…
- 关键词：ANCA ; Outcome ; Pauci ; immune glomerulonephritis ; Histopathological classes
- 刊名：BMC Nephrology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：16
- 期：1
- 全文大小：678 KB
- 刊物主题：Nephrology; Internal Medicine;
- 出版者：BioMed Central
- ISSN：1471-2369
文摘
Background The recently suggested distinct pathogenic pathways for myeloperoxidase (MPO) and proteinase 3 (PR3) anti-neutrophilic cytoplasmic antibodies (ANCA) associated vasculitis could result in different modes of presentation and outcome. Moreover, kidney outcome was related to a new histopathologic classification of pauci-immune glomerulonephritis. As reports were not always concordant, possible because differences in severity of organ lesions and ethnicity, we evaluated the outcome of a cohort of Central-East European patients with crescentic glomerulonephritis in relation with ANCA specificity and histopathological classification.