Antibodies to group A streptococcal virulence factors, SIC and DRS, increase predilection to GAS pyoderma

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• 作者：Mohan G Karmarkar ; Gouri P Hule ; Ainslie Cameron ; Preeti R Mehta…
• 关键词：Streptococcus pyogenes ; Post streptococcal glomerulonephritis ; Pyoderma ; Streptococcal inhibitor of complement
• 刊名：BMC Infectious Diseases
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：15
• 期：1
• 全文大小：694 KB
• 参考文献：1. Cunningham, MW (2000) Pathogenesis of group A streptococcal infections. Clin Microbiol Rev 13: pp. 470-511 CrossRef
  2. Walker, MJ, Barnett, TC, McArthur, JD, Cole, JN, Gillen, CM, Henningham, A (2014) Disease manifestations and pathogenic mechanisms of group a Streptococcus. Clin Microbiol Rev 27: pp. 264-301 CrossRef
  3. Akesson, P, Sjoholm, AG, Bjorck, L (1996) Protein SIC, a novel extracellular protein of Streptococcus pyogenes interfering with complement function. J Biol Chem 271: pp. 1081-8 CrossRef
  4. Binks, M, McMillan, D, Sriprakash, KS (2003) Genomic location and variation of the gene for CRS, a complement binding protein in the M57 strains of Streptococcus pyogenes. Infect Immun 71: pp. 6701-6 CrossRef
  5. Hartas, J, Sriprakash, KS (1999) Streptococcus pyogenes strains containing emm12 and emm55 possess a novel gene coding for distantly related SIC protein. Microb Pathog 26: pp. 25-33 CrossRef
  6. Sagar, V, Kumar, R, Ganguly, NK, Chakraborti, A (2008) Comparative analysis of emm type pattern of Group A Streptococcus throat and skin isolates from India and their association with closely related SIC, a streptococcal virulence factor. BMC Microbiol 8: pp. 150 CrossRef
  7. Hoe, NP, Kordari, P, Cole, R, Liu, M, Palzkill, T, Huang, W (2000) Human immune response to streptococcal inhibitor of complement, a serotype M1 group A Streptococcus extracellular protein involved in epidemics. J Infect Dis 182: pp. 1425-36 CrossRef
  8. Sriprakash, KS, Hartas, J, White, A (2002) Antibodies to streptococcal inhibitor of complement function and M peptides in a post-streptococcal glomerulonephritis endemic region of Australia. J Med Microbiol 51: pp. 589-94
  9. Yoshizawa, N (2000) Acute glomerulonephritis. Intern Med 39: pp. 687-94 CrossRef
  10. Skattum, L, Akesson, P, Truedsson, L, Sjoholm, AG (2006) Antibodies against four proteins from a Streptococcus pyogenes serotype M1 strain and levels of circulating mannan-binding lectin in acute poststreptococcal glomerulonephritis. Int Arch Allergy Immunol 140: pp. 9-19 CrossRef
  11. Baldwin, DS, Gluck, MC, Schacht, RG, Gallo, G (1974) The long-term course of poststreptococcal glomerulonephritis. Ann Intern Med 80: pp. 342-58 CrossRef
  12. Hoy, WE, White, AV, Dowling, A, Sharma, SK, Bloomfield, H, Tipiloura, BT (2012) Post-streptococcal glomerulonephritis is a strong risk factor for chronic kidney disease in later life. Kidney Int 81: pp. 1026-32 CrossRef
  13. Lopes, AA, Silveira, MA, Martinelli, RP, Rocha, H (2001) Association between race and incidence of end-stage renal disease secondary to glomerulonephritis: influence of the histologic type and presence of arterial hypertension. Rev Assoc Med Bras 47: pp. 78-84 CrossRef
  14. White, AV, Hoy, WE, McCredie, DA (2001) Childhood post-streptococcal glomerulonephritis as a risk factor for chronic renal disease in later life. Med J Aust 174: pp. 492-6
  15. Karmarkar, MG, Hule, GP, Hase, NK, Mehta, PR, Walter, SR, Sriprakash, KS (2013) Seroprevalence of Streptococcal Inhibitor of Complement (SIC) suggests association of streptococcal infection with chronic kidney disease. BMC Nephrol 14: pp. 101 CrossRef
  16. Karmarkar, MG, Venugopal, V, Joshi, L, Kamboj, R (2004) Evaluation & revaluation of upper limits of normal values of anti-streptolysin O & anti-deoxyribonuclease B in Mumbai. Indian J Med Res 119: pp. 26-8
  17. Husd
• 刊物主题：Infectious Diseases; Parasitology; Medical Microbiology; Tropical Medicine; Internal Medicine;
• 出版者：BioMed Central
• ISSN：1471-2334

文摘

Background Streptococcus pyogenes (group A streptococcus; GAS) is an etiological agent for pharyngitis, pyoderma, and invasive infections in humans. Pharyngitis and pyoderma may lead to serious immune sequelae such as rheumatic heart disease and post-streptococcal glomerulonephritis (PSGN). Streptococcal Inhibitor of Complement (SIC) and its orthologue, distantly related to SIC (DRS), are virulence factors expressed by only four of more than 100?M types of GAS. These four types (M1, M57, M12 and M55) are among the M types, which are associated with PSGN. In several populations PSGN has been shown to be a risk factor for chronic kidney disease (CKD) and end-stage renal disease (ESRD). Previous studies showed SIC or DRS antibody-prevalence was associated with PSGN, and seroprevalence of SIC antibodies is significantly high among CKD and ESRD patients in Mumbai. Methods Streptococcal isolates recovered from GAS pyoderma cases were typed. Seropositivity for SIC and DRS antibodies in subjects with pyoderma, PSGN pediatric cases, age matched healthy controls and non-GAS pyoderma cases were determined. Results We confirm in this study an association between seroprevalence to SIC and DRS antibodies, and PSGN in Mumbai population despite low point prevalence of M1, M12, M55 and M57. In addition we extended the study to GAS-pyoderma and non-GAS pyoderma cases. To our surprise, we found a positive association between the seroprevalence to SIC and DRS antibodies, and GAS-pyoderma owing to infection with diverse M types. The mechanism of increased predisposition to pyoderma owing to infection by diverse GAS among SIC or DRS antibody-positive population is not clear. Nonetheless, our findings could be explained by a phenomenon akin to antibody-dependent enhancement (ADE). Conclusions This is the first report showing a small number of GAS M types conferring predisposition to pyoderma by diverse types. Implications of this ADE-like phenomenon are discussed in the light of evolutionary advantage to GAS, vaccine design and control of renal diseases.