The Effects of Stress on Glutamatergic Transmission in the Brain
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  • 作者:Ti-Fei Yuan ; Gonglin Hou
  • 关键词:Stress ; Glutamatergic transmission ; AMPA ; NMDA ; Receptor ; Synaptic plasticity
  • 刊名:Molecular Neurobiology
  • 出版年:2015
  • 出版时间:June 2015
  • 年:2015
  • 卷:51
  • 期:3
  • 页码:1139-1143
  • 全文大小:217 KB
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  • 作者单位:Ti-Fei Yuan (1)
    Gonglin Hou (2)

    1. School of Psychology, Nanjing Normal University, Nanjing, China
    2. Department of Psychology, Zhejiang Sci-Tech University, Hangzhou, China
  • 刊物主题:Neurosciences; Neurobiology; Cell Biology; Neurology;
  • 出版者:Springer US
  • ISSN:1559-1182
文摘
Stress leads to detrimental effects on brain functions and results in various diseases. Recent studies highlight the involvement of glutamatergic transmission in pathogenesis of depressive behaviors and fears. Acute stress generates different impacts on the excitatory transmission compared to chronic stress. Different neuromodulators and epigenetic factors also participate in the alteration of synaptic transmission and the regulation of synaptic plasticity. Restoration of the glutamatergic transmission in stress-affected brain areas therefore provides novel directions of therapeutic interventions against stress.

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