Not only smoking is deadly: fatal ingestion of e-juice—a case report

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• 作者：Svenja Bartschat ; Katja Mercer-Chalmers-Bender…
• 关键词：Nicotine ; Intoxication ; E ; cigarette ; Suicide ; Post ; mortem redistribution ; Organ distribution
• 刊名：International Journal of Legal Medicine
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：129
• 期：3
• 页码：481-486
• 全文大小：156 KB
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• 作者单位：Svenja Bartschat (1)
  Katja Mercer-Chalmers-Bender (1)
  Justus Beike (1)
  Markus A. Rothschild (1)
  Martin Jübner (1)
  
  1. Institute of Legal Medicine, University Hospital of Cologne, Cologne, Germany
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Forensic Medicine
  Medical Law
  Medicine/Public Health, general
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1437-1596

文摘

A fatal case of nicotine intoxication by oral intake of a nicotine solution, sold via the Internet, is reported. The concentrated nicotine solution (72?mg/mL) is usually diluted with polypropylene, polyethylene glycol or glycerine, respectively, in order to allow the user to generate their own solution for vaporisation in electronic cigarettes (e-juice). A 34-year-old man was found lifeless by his parents, who reported that their son had been in good health and had shown no hints of suicidal behaviour. The medicolegal autopsy revealed unspecific findings. Toxicological analysis revealed nicotine concentrations of 5.5?mg/L in femoral venous blood, 136?mg/L in heart blood, 12.0?mg/kg in brain tissue, 42.6?mg/kg in kidney tissue, 89.5?mg/kg in lung tissue and a total amount of 3,950?mg in the gastric contents. Cotinine concentrations were 0.9?mg/L in femoral venous blood, 7.6?mg/L in heart blood, 0.4?mg/kg in brain tissue, 0.9?mg/kg in kidney tissue and 0.8?mg/kg in lung tissue. No cotinine was detected in the gastric contents. The nicotine level measured in the femoral blood was in good accordance with the levels reported in other fatal cases caused by oral or patch application of nicotine. Moreover, the high level of nicotine in lung and kidney tissue, compared to that within femoral blood, strikingly emphasises the strong effect of post-mortem redistribution, underlined by the comparably low concentration of nicotine in the brain. The extremely high level of nicotine in the heart blood is more likely due to the high concentration in the gastric contents, due to oral intake, and by accumulation of the basic substance in the acidic gastric contents. This further highlights the effect of post-mortem redistribution. The mother of the deceased later admitted that her son had been suffering from psychosis and that she found a package containing five nicotine solution vials?of the brand “Titanium Ice-(of 50?mL each). Three of the vials were empty. The nicotine concentration in the e-juice Titanium Ice was confirmed by HPLC analysis.