Neoadjuvante Therapie bei Tumoren des oberen Gastrointestinaltrakts

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• 作者：Prof. Dr. I. Gockel MBA ; A. Hoffmeister ; F. Lordick
• 关键词：Radiochemotherapy ; Side effects ; Medical oncological management ; Endoscopic therapy ; Preoperative conditioning
• 刊名：Der Chirurg
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：86
• 期：11
• 页码：1014-1022
• 全文大小：519 KB
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• 作者单位：Prof. Dr. I. Gockel MBA (1)
  A. Hoffmeister (2)
  F. Lordick (3)
  
  1. Klinik für Viszeral-, Transplantations-, Thorax- und Gefäßchirurgie, Department für Operative Medizin (DOPM), Universitätsklinikum Leipzig, AöR, Liebigstr. 20, 04103, Leipzig, Deutschland
  2. Klinik für Gastroenterologie, Universitätsklinikum Leipzig, AöR, Leipzig, Deutschland
  3. Universitäres Krebszentrum Leipzig (UCCL), Universitätsklinikum Leipzig, AöR, Leipzig, Deutschland
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Surgery
  Cardiac Surgery
  Pediatric Surgery
  Plastic Surgery
  Traumatic Surgery
  Vascular Surgery
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1433-0385

文摘

Recent studies could demonstrate that neoadjuvant chemotherapy and radiochemotherapy for esophageal and gastric cancer do not significantly increase the risk of postoperative morbidity and mortality as compared to surgery alone. With respect to patient safety and effectiveness of neoadjuvant concepts, quality assured performance of each treatment modality and close interdisciplinary cooperation play an important role. The majority of potential side effects and complications, which might occur during neoadjuvant therapy can be adequately controlled by correct prophylaxis and professional medical complication management. Complications before, during and after neoadjuvant therapy of upper gastrointestinal tract tumors can also be caused by the tumor itself or by medicinal therapy. These comprise bleeding, fistulas, perforations and stenoses. Modern endoscopic techniques are the therapy of choice in these situations. Preoperative conditioning during the period of neoadjuvant therapy opens the possibility of reduced postoperative complications to patients with tumors of the upper gastrointestinal tract.