Diagnostik und Therapie des ?sophaguskarzinoms

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• 作者：Prof. Dr. R. Kiesslich (1)
  M. M?hler (1)
  T. Hansen (2)
  P.R. Galle (1)
  H. Lang (3)
  I. Gockel (3)
  
• 关键词：?sophaguskarzinome ; Endoskopie ; Tumorstaging ; Operatives Vorgehen ; Multimodale Therapie ; Esophageal neoplasms ; Endoscopy ; Neoplasm staging ; Surgical management ; Combined modality therapy
• 刊名：Der Internist
• 出版年：2012
• 出版时间：November 2012
• 年：2012
• 卷：53
• 期：11
• 页码：1315-1329
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  34. Thallinger CM, Raderer M, Hejna M (2011) Esophageal cancer: a critical evaluation of systemic second-line therapy. J?Clin Oncol 29:4709-714
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• 作者单位：Prof. Dr. R. Kiesslich (1)
  M. M?hler (1)
  T. Hansen (2)
  P.R. Galle (1)
  H. Lang (3)
  I. Gockel (3)
  
  1. Medizinische Klinik und Poliklinik, Universit?tsmedizin Mainz, Langenbeckstr. 1, 55131, Mainz, Deutschland
  2. Institut für Pathologie, Universit?tsmedizin Mainz, Mainz, Deutschland
  3. Klinik für Allgemein- und Abdominalchirurgie, Universit?tsmedizin Mainz, Mainz, Deutschland
  
• ISSN：1432-1289

文摘

The prognosis for patients with advanced esophageal cancer is poor. Proper risk assessment and knowledge of tumor biology may facilitate early diagnosis of adenocarcinomas and squamous cell cancer of the esophagus. New endoscopic techniques are available (e.g., (virtual) chromoendoscopy, autofluorescence, and endomicroscopy) for the early detection of cancer. Endoscopic therapy with complete resection of mucosal cancers offers long-term survival. En bloc resection combined with the removal of locoregional lymph nodes is the surgical option of choice for locally advanced cancer. In this respect, minimally invasive surgery offers the patient numerous advantages. Multimodal therapy results in better outcome for defined cancer stages and includes surgery, chemotherapy and chemoradiation. Multimodal treatment should always be individualized and requires cooperation of all subspecialties (tumor board conference). New chemotherapeutic strategies may offer improved survival but may also include new side effects. Patients with inoperable esophageal cancer also benefit from multimodal treatment.