Association of surgical resection and survival in patients with malignant primary osseous spinal neoplasms from the Surveillance, Epidemiology, and End Results (SEER) database
详细信息 查看全文
- 作者：Debraj Mukherjee (1)
Kaisorn L. Chaichana (2)
Scott L. Parker (3)
Ziya L. Gokaslan (2)
Matthew J. McGirt (3) - 关键词：Biopsy ; Chondrosarcoma ; Chordomas ; Ewing’s sarcoma ; Osteosarcoma ; Survival ; Surgery
- 刊名：European Spine Journal
- 出版年：2013
- 出版时间：June 2013
- 年：2013
- 卷：22
- 期：6
- 页码：1375-1382
- 全文大小：360KB
- 参考文献：1. American Cancer Society (2008) Cancer Facts & Figures 2008. American Cancer Society, Atlanta
2. Arai Y, Kun LE, Brooks MT, Fairclough DL, Fontanesi J, Meyer WH et al (1991) Ewing’s sarcoma: local tumor control and patterns of failure following limited-volume radiation therapy. Int J Radiat Oncol Biol Phys 21:1501-508 CrossRef
3. Bacci G, Boriani S, Balladelli A, Barbieri E, Longhi A, Alberghini M et al (2009) Treatment of nonmetastatic Ewing’s sarcoma family tumors of the spine and sacrum: the experience from a single institution. Eur Spine J 18:1091-095 CrossRef
4. Bergh P, Gunterberg B, Meis-Kindblom JM, Kindblom LG (2001) Prognostic factors and outcome of pelvic, sacral, and spinal chondrosarcomas: a center-based study of 69 cases. Cancer 91:1201-212 CrossRef
5. Bergh P, Kindblom LG, Gunterberg B, Remotti F, Ryd W, Meis-Kindblom JM (2000) Prognostic factors in chordoma of the sacrum and mobile spine: a study of 39 patients. Cancer 88:2122-134 CrossRef
6. Boriani S, Bandiera S, Biagini R, Bacchini P, Boriani L, Cappuccio M et al (2006) Chordoma of the mobile spine: fifty years of experience. Spine (Phila Pa 1976) 31:493-03 CrossRef
7. Boriani S, De Iure F, Bandiera S, Campanacci L, Biagini R, Di Fiore M et al (2000) Chondrosarcoma of the mobile spine: report on 22 cases. Spine (Phila Pa 1976) 25:804-12 CrossRef
8. Bovill EG Jr, Kung’u A, Bencivenga A, Jeshrani MK, Mbindyo BS, Heda PM (1985) An epidemiological study of osteogenic sarcoma in Kenya: the variations in incidence between ethnic groups and geographic regions, 1968-978. Int Orthop 9:59-3 CrossRef
9. Cheng EY, Ozerdemoglu RA, Transfeldt EE, Thompson RC Jr (1999) Lumbosacral chordoma. Prognostic factors and treatment. Spine (Phila Pa 1976) 24:1639-645 CrossRef
10. DeLaney TF, Park L, Goldberg SI, Hug EB, Liebsch NJ, Munzenrider JE et al (2005) Radiotherapy for local control of osteosarcoma. Int J Radiat Oncol Biol Phys 61:492-98 CrossRef
11. Dorfman HD, Czerniak B (1995) Bone cancers. Cancer 75:203-10 CrossRef
12. Evans RG, Nesbit ME, Gehan EA, Garnsey LA, Burgert O Jr, Vietti TJ et al (1991) Multimodal therapy for the management of localized Ewing’s sarcoma of pelvic and sacral bones: a report from the second intergroup study. J Clin Oncol 9:1173-180
13. Fourney DR, Rhines LD, Hentschel SJ, Skibber JM, Wolinsky JP, Weber KL et al (2005) En bloc resection of primary sacral tumors: classification of surgical approaches and outcome. J Neurosurg Spine 3:111-22 CrossRef
14. Gherlinzoni F, Picci P, Bacci G, Campanacci D (1992) Limb sparing versus amputation in osteosarcoma. Correlation between local control, surgical margins and tumor necrosis: Istituto Rizzoli experience. Ann Oncol 3(Suppl 2):S23–S27 CrossRef
15. Grubb MR, Currier BL, Pritchard DJ, Ebersold MJ (1994) Primary Ewing’s sarcoma of the spine. Spine (Phila Pa 1976) 19:309-13 CrossRef
16. Hsieh PC, Xu R, Sciubba DM, McGirt MJ, Nelson C, Witham TF et al (2009) Long-term clinical outcomes following en bloc resections for sacral chordomas and chondrosarcomas: a series of twenty consecutive patients. Spine (Phila Pa 1976) 34:2233-239 CrossRef
17. Ito E, Saito K, Okada T, Nagatani T, Nagasaka T (2010) Long-term control of clival chordoma with initial aggressive surgical resection and gamma knife radiosurgery for recurrence. Acta Neurochir (Wien) 152:57-7 discussion 67 CrossRef
18. Larsson SE, Lorentzon R (1974) The incidence of malignant primary bone tumours in relation to age, sex and site. A study of osteogenic sarcoma, chondrosarcoma and Ewing’s sarcoma diagnosed in Sweden from 1958 to 1968. J Bone Jt Surg Br 56B:534-40
19. Link MP, Goorin AM, Horowitz M, Meyer WH, Belasco J, Baker A et al (1991) Adjuvant chemotherapy of high-grade osteosarcoma of the extremity. Updated results of the Multi-Institutional Osteosarcoma Study. Clin Orthop Relat Res 8-4
20. Marco RA, Gentry JB, Rhines LD, Lewis VO, Wolinski JP, Jaffe N et al (2005) Ewing’s sarcoma of the mobile spine. Spine (Phila Pa 1976) 30:769-73 CrossRef
21. Marmor E, Rhines LD, Weinberg JS, Gokaslan ZL (2001) Total en bloc lumbar spondylectomy. Case report. J Neurosurg 95:264-69
22. McMaster ML, Goldstein AM, Bromley CM, Ishibe N, Parry DM (2001) Chordoma: incidence and survival patterns in the United States, 1973-995. Cancer Causes Control 12:1-1 CrossRef
23. Navid F, Willert JR, McCarville MB, Furman W, Watkins A, Roberts W et al (2008) Combination of gemcitabine and docetaxel in the treatment of children and young adults with refractory bone sarcoma. Cancer 113:419-25 CrossRef
24. Oyemade GA, Abioye AA (1982) Primary malignant tumors of bone: incidence in Ibadan, Nigeria. J Natl Med Assoc 74:65-8
25. Ozaki T, Flege S, Liljenqvist U, Hillmann A, Delling G, Salzer-Kuntschik M et al (2002) Osteosarcoma of the spine: experience of the Cooperative Osteosarcoma Study Group. Cancer 94:1069-077 CrossRef
26. Paulino AC, Nguyen TX, Mai WY (2007) An analysis of primary site control and late effects according to local control modality in non-metastatic Ewing sarcoma. Pediatr Blood Cancer 48:423-29 CrossRef
27. Price CH, Jeffree GM (1977) Incidence of bone sarcoma in SW England, 1946-4, in relation to age, sex, tumour site and histology. Br J Cancer 36:511-22 CrossRef
28. Rao G, Suki D, Chakrabarti I, Feiz-Erfan I, Mody MG, McCutcheon IE et al (2008) Surgical management of primary and metastatic sarcoma of the mobile spine. J Neurosurg Spine 9:120-28 CrossRef
29. Sciubba DM, Okuno SH, Dekutoski MB, Gokaslan ZL (2009) Ewing and osteogenic sarcoma: evidence for multidisciplinary management. Spine (Phila Pa 1976) 34:S58–S68 CrossRef
30. Shives TC, Dahlin DC, Sim FH, Pritchard DJ, Earle JD (1986) Osteosarcoma of the spine. J Bone Jt Surg Am 68:660-68
31. Shives TC, McLeod RA, Unni KK, Schray MF (1989) Chondrosarcoma of the spine. J Bone Jt Surg Am 71:1158-165
32. Stacchiotti S, Marrari A, Tamborini E, Palassini E, Virdis E, Messina A et al (2009) Response to imatinib plus sirolimus in advanced chordoma. Ann Oncol 20:1886-894 CrossRef
33. Sundaresan N, Rosen G, Boriani S (2009) Primary malignant tumors of the spine. Orthop Clin North Am 40:21-6, v
34. Sundaresan N, Rosen G, Huvos AG, Krol G (1988) Combined treatment of osteosarcoma of the spine. Neurosurgery 23:714-19 CrossRef
35. Wagner LM, McAllister N, Goldsby RE, Rausen AR, McNall-Knapp RY, McCarville MB et al (2007) Temozolomide and intravenous irinotecan for treatment of advanced Ewing sarcoma. Pediatr Blood Cancer 48:132-39 CrossRef
36. Weber KL (2002) Current concepts in the treatment of Ewing’s sarcoma. Expert Rev Anticancer Ther 2:687-94 CrossRef
37. York JE, Berk RH, Fuller GN, Rao JS, Abi-Said D, Wildrick DM et al (1999) Chondrosarcoma of the spine: 1954 to 1997. J Neurosurg 90:73-8
38. York JE, Kaczaraj A, Abi-Said D, Fuller GN, Skibber JM, Janjan NA et al (1999) Sacral chordoma: 40-year experience at a major cancer center. Neurosurgery 44:74-9 (discussion 79-0) CrossRef - 作者单位：Debraj Mukherjee (1)
Kaisorn L. Chaichana (2)
Scott L. Parker (3)
Ziya L. Gokaslan (2)
Matthew J. McGirt (3)
1. Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA
2. Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD, 21287, USA
3. Department of Neurosurgery, Vanderbilt Medical Center, 1500 21st Ave South, Suite 1506, Nashville, TN, 37212, USA - ISSN：1432-0932
文摘
Objective Malignant osseous spinal neoplasms are aggressive tumors associated with poor outcomes despite aggressive multidisciplinary measures. While surgical resection has been shown to improve short-term local disease control, it remains debated whether surgical resection is associated with improved overall survival in patients with malignant primary osseous spinal neoplasms. The aim of this manuscript is to review survival data from a US cancer registry spanning 30?years to determine if surgical resection was independently associated with overall survival. Methods The SEER registry (1973-003) was queried to identify cases of histologically confirmed primary spinal chordoma, chondrosarcoma, osteosarcoma, or Ewing’s sarcoma of the mobile spine and pelvis. Patients with systemic metastasis were excluded. Age, gender, race, tumor location, and primary treatments were identified. Extent of local tumor invasion was classified as confined within periosteum versus extension beyond periosteum to surrounding tissues. The association of surgical resection with overall survival was assessed via Cox analysis adjusting for age, radiotherapy, and tumor invasiveness. Results 827 patients were identified with non-metastatic primary osseous spinal neoplasms (215 chordoma, 282 chondrosarcoma, 158 osteosarcoma, 172 Ewing’s sarcoma). Overall, median survival was histology specific (chordoma, 96?months; Ewing’s sarcoma, 90?months; chondrosarcoma, 88?months; osteosarcoma, 18?months). Adjusting for age, radiation therapy, and extent of local tumor invasion in patients with isolated (non-metastatic) spine tumors, surgical resection was independently associated with significantly improved survival for chordoma [hazard ratio (95?% confidence interval; 0.617 (0.25-.98)], chondrosarcoma [HR (95?%CI); 0.153 (0.07-.36)], osteosarcoma [HR (95?%CI); 0.382 (0.21-.69)], and Ewing’s sarcoma [HR (95?%CI); 0.494 (0.26-.96)]. Conclusion In our analysis of a 30-year US population-based cancer registry (SEER), patients undergoing surgical resection of primary spinal chordoma, chondrosarcoma, Ewing’s sarcoma, or osteosarcoma demonstrated prolonged overall survival independent of patient age, extent of local invasion, or location. Surgical resection may play a role in prolonging survival in the multi-modality treatment of patients with these malignant primary osseous spinal neoplasms.