Direct renin inhibitors: ONTARGET for success?

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• 作者：Yasmin Pasha ; Paul Gusbeth-Tatomir ; Adrian Covic and David Goldsmith
• 关键词：ACE ; inhibitor ; Angiotensin II receptor blocker ; Aliskiren ; Chronic kidney disease ; Direct renin inhibitors ; Renin angiotensin system ; Renin inhibitors
• 刊名：International Urology and Nephrology
• 出版年：2009
• 出版时间：June, 2009
• 年：2009
• 卷：41
• 期：2
• 页码：341-355
• 全文大小：266.7 KB

文摘

Direct renin inhibitors are the first new class of antihypertensive to emerge since angiotensin II receptor blockers. We discuss their reno- and cardioprotective potential, based on extrapolation from animal models and phase three trials that are currently ongoing. This paper reviews the potential benefits of direct renin inhibitors (DRIs), the only new anti-hypertensive class developed in the last decade, as compared to pre-existing classes of drug inhibiting more downstream, such as Angiotensin Converting Enzyme inhibitors (ACEI), Angiotensin 2 Receptor Blockers (ARBS).