The role of transmembrane protein 27 (TMEM27) in islet physiology and its potential use as a beta cell mass biomarker

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• 作者：J. Altirriba ; R. Gasa ; S. Casas ; M. J. Ram¨ªrez-Bajo ; S. Ros ; A. Gutierrez-Dalmau ; M. C. Ruiz de Villa ; A. Barbera and R. Gomis
• 关键词：Beta cell ; Islet ; Biomarker ; Insulin secretion ; Proliferation ; TMEM27
• 刊名：Diabetologia
• 出版年：2010
• 出版时间：July, 2010
• 年：2010
• 卷：53
• 期：7
• 页码：1406-1414
• 全文大小：395.3 KB

文摘

Aims/hypothesis Transmembrane protein 27 (TMEM27) is a membrane protein cleaved and shed by pancreatic beta cells that has been proposed as a beta cell mass biomarker. Despite reports of its possible role in insulin exocytosis and cell proliferation, its function in beta cells remains controversial. We aimed to characterise the function of TMEM27 in islets and its potential use as a beta cell mass biomarker.