CORM-2 inhibits TXNIP/NLRP3 inflammasome pathway in LPS-induced acute lung injury

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• 作者：Lei Jiang ; Dongsheng Fei ; Rui Gong ; Wei Yang ; Wei Yu ; Shangha Pan…
• 关键词：Carbon monoxide ; Acute lung injury ; NLRP3 inflammasome ; TXNIP
• 刊名：Inflammation Research
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：65
• 期：11
• 页码：905-915
• 全文大小：8,870 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Immunology
  Pharmacology and Toxicology
  Allergology
  Dermatology
  Neurology
  Rheumatology
  
• 出版者：Birkh盲user Basel
• ISSN：1420-908X
• 卷排序：65

文摘

ObjectiveAccumulated studies suggest that exogenously administered carbon monoxide is beneficial for the resolution of acute lung inflammation. The present study aimed to examine the effects and the underlying mechanisms of CORM-2 on thioredoxin-interacting protein (TXNIP)/NLRP3 inflammasome pathway in lipopolysaccharide (LPS)-induced acute lung injury (ALI).