参考文献:1. Kestelyn P, Bogaerts J, Meheus A (1987) Gonorrheal keratoconjunctivitis in African adults. Sex Transm Dis 14(4):191-94 CrossRef 2. Hegde V, Smith G, Choi J, Pagliarini S (2005) A case of gonococcal kerato-conjunctivitis mimicking orbital cellulitis. Acta Ophthalmol Scand 83(4):511-12 CrossRef 3. Wan WL, Farkas GC, May WN, Robin JB (1986) The clinical characteristics and course of adult gonococcal conjunctivitis. Am J Ophthalmol 102(5):575-83 CrossRef 4. Duke-Elder S (1965) Diseases of the outer eye. In: system of ophthalmology Vol. 8. Part 1. CV Mosby Co, St. Louis, 167-74 5. Lee JS, Choi HY, Lee JE, Lee SH, Oum BS (2002) Gonococcal keratoconjunctivitis in adults. Eye 16(5):646-49 CrossRef 6. Kawashima M, Kawakita T, Den S, Tomita M, Shimazaki J (2009) Surgical management of corneal perforation secondary to gonococcal keratoconjunctivitis. Eye 23(2):339-44 CrossRef 7. Gambrelle J, Ponceau B, Duquesne N, Crepet H, Fleury J, Burillon C, Grange JD, Kodjikian L (2007) Gonococcal conjunctivitis complicated by perforating corneal abscess in an adult. J Fr Ophtalmol 30(7):e18 CrossRef 8. Papp JR, Schachter J, Gaydos CA, Van Der Pol B Centres for Disease Control and Prevention (2014) Recommendations for the laboratory-based detection of / Chlamydia trachomatis and / Neisseria gonorrhoeae 2014. MMWR Recomm Rep 63:1-9 9. Bachmann LH, Johnson RE, Cheng H, Markowitz LE, Papp JR, Hook EW (2009) Nucleic acid amplification tests for diagnosis of / Neisseria gonorrhoeae oropharyngeal infections. J Clin Microbiol 47(4):902-07 CrossRef 10. Bachmann LH, Johnson RE, Cheng H, Markowitz LE, Papp JR, Palella FJ Jr, Hook EW (2010) Nucleic acid amplification tests for diagnosis of / Neisseria gonorrhoeae and / Chlamydia trachomatis rectal infections. J Clin Microbiol 48(5):1827-832 CrossRef 11. Haimovici R, Roussel TJ (1989) Treatment of gonococcal conjunctivitis with single-dose intramuscular ceftriaxone. Am J Ophthalmol 102:511-14 CrossRef 12. Centers for Disease Control and Prevention (CDC) (2012) Update to CDC’s sexually transmitted diseases treatment guidelines, 2010: oral cephalosporins no longer a recommended treatment for gonococcal infections. MMWR Morb Mortal Wkly Rep 61(31):590-94 13. Tanaka M, Matsumoto T, Sakumoto M, Takahashi K, Saika T, Kabayashi I, Kumazawa J (1998) Reduced clinical efficacy of pazufloxacin against gonorrhea due to high prevalence of quinolone-resistant isolates with the GyrA mutation. The pazufloxacin STD group. Antimicrob Agents Chemother 42(3):579-82 14. Tanaka M, Nakayama H, Haraoka M, Saika T (2000) Antimicrobial resistance of / Neisseria gonorrhoeae and high prevalence of ciprofloxacin-resistant isolates in Japan, 1993-998. J Clin Microbiol 38(2):521-25 15. Rothenberg R, Voigt R (1988) Epidemiologic aspects of control of penicillinase-producing / Neisseria gonorrhoeae. Sex Transm Dis 15(4):211-16 CrossRef 16. Duncan S, Duncan CJ (2010) The emerging threat of untreatable gonococcal infection. N Engl J Med 366(22):2136 CrossRef 17. Kirkcaldy RD, Weinstock HS, Moore PC, Philip SS, Wiesenfeld HC, Papp JR, Kerndt PR, Johnson S, Ghanem KG, Hook EW (2014) The efficacy and safety of gentamicin plus azithromycin and gemifloxacin plus azithromycin as treatment of uncomplicated gonorrhea. Clin Infect Dis 59(8):1083-091 CrossRef 18. American Academy of Paediatrics (1980) Prophylaxis and treatment of neonatal gonococcal infections. Paediatrics 65:1047-048 19.
作者单位:Elizabeth McElnea (1) Patrick Stapleton (2) Sheryar Khan (1) John Stokes (1) Gareth Higgins (1)
1. Department of Ophthalmology, Waterford Regional Hospital, Waterford, Co. Waterford, Ireland 2. Department of Microbiology, Waterford Regional Hospital, Waterford, Co. Waterford, Ireland
刊物类别:Medicine
刊物主题:Medicine & Public Health Ophthalmology
出版者:Springer Netherlands
ISSN:1573-2630
文摘
We describe the presentation and subsequent management of a case of keratitis caused by Neisseria gonorrhoeae. A thirty-nine year old gentleman presented with a purulent ocular discharge. Corneal melt with corneal perforation occurred. Neisseria gonorrhoeae was cultured. Systemic and topical antibiotics were given. Deep lamellar keratoplasty was performed for corneal perforation. At three months post treatment no recurrence of infection was noted. The possibility of Neisseria gonorrhoeaea keratitis should always be considered in patients with a purulent ocular discharge even if the case?history is not immediately suggestive of the same. Severe gonococcal keratitis may be unilateral. Deep lamellar keratoplasty can be considered as a therapeutic option in patients with severe gonococcal keratitis.